2-propylquinoline

Base Information

• Chemical Name: 2-propylquinoline
• CAS No.: 1613-32-7
• Molecular Formula: C12H13 N
• Molecular Weight: 171.242
• Hs Code.: 2933499090
• Mol file: 1613-32-7.mol

Synonyms:2-Propylquinoline;2-n-Propylquinoline

Chemical Property of 2-propylquinoline

Chemical Property:

• Vapor Pressure: 0.0142mmHg at 25°C
• Melting Point: 68.75°C (estimate)
• Refractive Index: 1.5886
• Boiling Point: 266.4°C at 760 mmHg
• PKA: 5.91±0.40(Predicted)
• Flash Point: 106.9°C
• PSA: 12.89000
• Density: 1.03g/cm³
• LogP: 3.18730

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-propylquinoline

There total 60 articles about 2-propylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-Pentyne (627-19-0) + o-aminobenzaldehyde (529-23-7) → 2-n-Propylquinoline (1613-32-7)

Guidance literature:

With pyrrolidine; copper(l) iodide; In acetonitrile; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jo101103a

Reference yield: 89.0%

4-chloro-2-(2-chloro-1-propenyl)quinoline (634605-96-2) → 2-n-Propylquinoline (1613-32-7)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; at 20 ℃;

DOI:10.3987/com-03-9839

Reference yield: 80.0%

2-Aminobenzyl alcohol (5344-90-1) + 2-Pentanone (107-87-9) → 2-n-Propylquinoline (1613-32-7)

Guidance literature:

With sodium methylate; C₂₇H₃₀ClNORu; In methanol; at 20 ℃; for 6h; Catalytic behavior; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.inorgchem.0c00955

upstream raw materials:

tetrahydrofuran

quinoline

allylmagnesium bromide

2-methylquinoline

Downstream raw materials:

2-propyl-5,6,7,8-tetrahydro-quinoline

2-n-Propyl-1,2,3,4-tetrahydroquinoline

2-methylquinoline

Refernces

• 1、 Qin, Lei,Zheng, Daijun,Cui, Baodong,Wan, Nanwei,Zhou, Xiaojian,Chen, Yongzheng. "Bio-mediated oxidative resolution of racemic 2-substituted 1,2,3,4-tetrahydroquinolines". . p. 2403 - 2405. Retrieved 2016.
• 2、 Eisch,Comfort. "-". . p. 2288,2292. Retrieved 1975.
• 3、 Fakhfakh, Mohamed A.,Franck, Xavier,Fournet, Alain,Hocquemiller, Reynald,Figadère, Bruno. "Expeditious preparation of 2-substituted quinolines". . p. 3847 - 3850. Retrieved 2001.
• 4、 Yun, Xue-Jing,Zhu, Jing-Wei,Jin, Yan,Deng, Wei,Yao, Zi-Jian. "Half-Sandwich Ruthenium Complexes for One-Pot Synthesis of Quinolines and Tetrahydroquinolines: Diverse Catalytic Activity in the Coupled Cyclization and Hydrogenation Process". supporting information. p. 7841 - 7851. Retrieved 2020/06/04.
• 5、 Mahajan, Akhil,Arya, Anju,Chundawat, Tejpal Singh. "Green synthesis of silver nanoparticles using green alga (Chlorella vulgaris) and its application for synthesis of quinolines derivatives". supporting information. p. 1926 - 1937. Retrieved 2019/05/17.