L-DICENTRINE

Base Information

• Chemical Name: L-DICENTRINE
• CAS No.: 28832-07-7
• Molecular Formula: C₂₀H₂₁NO₄
• Molecular Weight: 339.391
• Mol file: 28832-07-7.mol

Synonyms:5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline,6,7,7a,8-tetrahydro-10,11-dimethoxy-7-methyl-, (R)-; 6ab-Aporphine,9,10-dimethoxy-1,2-(methylenedioxy)- (8CI); (-)-Dicentrine; (R)-(-)-Dicentrine;L-Dicentrine; NSC 251699

Chemical Property of L-DICENTRINE

Chemical Property:

• Vapor Pressure: 2.12E-09mmHg at 25°C
• Boiling Point: 480.7°Cat760mmHg
• PKA: 6.65±0.20(Predicted)
• Flash Point: 142.7°C
• PSA: 40.16000
• Density: 1.266g/cm³
• LogP: 3.12250

Purity/Quality:

95%-98% ^*data from raw suppliers

L-Dicentrine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A natural vascular alpha 1-adrenoceptor antagonist but less prevalent than the D-isomer. It markedly inhibits the contraction of rat stomach muscle strips induced by 5-HT, histamine, K+ and Ca2+ after high K+ depolarization, showing a non-competitive antagonism and could be a potential muscle relaxant. Studies suggest that it has protective effect of on acute myocardial Iichemia and anoxia lesion.

Technology Process of L-DICENTRINE

There total 3 articles about L-DICENTRINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H21NO6 → R-(-)-dicentrine (28832-07-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃;

DOI:10.1111/cbdd.13390

Reference yield:

→ R-(-)-dicentrine (28832-07-7)

Guidance literature:

With D-tartaric acid; L-Tartaric acid;

Reference yield:

(-)-phanostenine (25368-02-9,111032-23-6) → R-(-)-dicentrine (28832-07-7)

Guidance literature:

upstream raw materials:

(-)-phanostenine

Refernces