cefazolin delta-2-methyl ester

Base Information

• Chemical Name: cefazolin delta-2-methyl ester
• CAS No.: 79239-19-3
• Molecular Formula: C15H16 N8 O4 S3
• Molecular Weight: 468.541
• Mol file: 79239-19-3.mol

Synonyms:cefazolin delta-2-methyl ester

Chemical Property of cefazolin delta-2-methyl ester

Chemical Property:

• PSA: 223.93000
• LogP: -0.21890

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cefazolin delta-2-methyl ester

There total 4 articles about cefazolin delta-2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cefazolin sodium (27164-46-1) + methyl iodide (74-88-4) → delta-3 methyl ester of cefazolin (79239-19-3)

Guidance literature:

In N,N-dimethyl-formamide; for 3h; Ambient temperature;

DOI:10.1002/jps.2600790912

Reference yield:

cefazolin (25953-19-9) + methyl iodide (74-88-4) → delta-3 methyl ester of cefazolin (79239-19-3)

Guidance literature:

In 1,4-dioxane; N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1248/cpb.44.599

Reference yield:

delta-2-methyl ester of cefazolin (117929-10-9) → delta-3 methyl ester of cefazolin (79239-19-3)

Guidance literature:

With water; at 40 ℃; Rate constant; pH 7.4;

DOI:10.1002/jps.2600790912

upstream raw materials:

delta-2-methyl ester of cefazolin

cefazolin sodium

methyl iodide

(6R,7R)-3-(5-Methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-7-(2-tetrazol-1-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid methyl ester

Downstream raw materials:

delta-2-methyl ester of cefazolin

cefazolin

2-mercapto-5-methyl-1,3,4-thiadiazole

(6R,7R)-3-(5-Methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-7-(2-tetrazol-1-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid methyl ester

Refernces

• 1、 Saab,Hussain,Patel,Dittert. "Synthesis and mechanisms of decomposition of some cephalosporin prodrugs". . p. 802 - 805. Retrieved 2007/10/02.