2,6-Dimethylpiperidine

Base Information

• Chemical Name: 2,6-Dimethylpiperidine
• CAS No.: 504-03-0
• Deprecated CAS: 149300-91-4,884380-24-9,884380-24-9
• Molecular Formula: C7H15 N
• Molecular Weight: 113.203
• Hs Code.: 29333999
• European Community (EC) Number: 207-981-6
• NSC Number: 760379,63890,7513
• UNII: 329I5805BP
• DSSTox Substance ID: DTXSID8048527
• Nikkaji Number: J22.051E
• Wikipedia: 2,6-Dimethylpiperidine
• Wikidata: Q4596811
• NCI Thesaurus Code: C76789
• ChEMBL ID: CHEMBL2104431
• Mol file: 504-03-0.mol

Synonyms:2,6-lupetidine;nanofin;nanofin hydrochloride;nanophyn

Chemical Property of 2,6-Dimethylpiperidine

Chemical Property:

• Appearance/Colour: clear colorless to slightly yellow liquid
• Vapor Pressure: 11.3mmHg at 25°C
• Melting Point: <-20°C
• Refractive Index: n20/D 1.4394(lit.)
• Boiling Point: 127.1 °C at 760 mmHg
• PKA: 10.82±0.10(Predicted)
• Flash Point: 11 ºC
• PSA: 12.03000
• Density: 0.84
• LogP: 1.86570
• Storage Temp.: Flammables area
• Sensitive.: Air Sensitive
• Water Solubility.: MISCIBLE
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 113.120449483
• Heavy Atom Count: 8
• Complexity: 62.8

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dimethylpiperidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xi,C
• Statements: 11-36/37/38-34
• Safety Statements: 16-26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Cyclic
• Canonical SMILES: CC1CCCC(N1)C

Technology Process of 2,6-Dimethylpiperidine

There total 10 articles about 2,6-Dimethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,6-dimethylpyridine (108-48-5) → 2.6-dimethylpiperidine (504-03-0)

Guidance literature:

With hydrogen; In isopropyl alcohol; at 160 ℃; for 24h; under 45004.5 Torr; Autoclave;

DOI:10.1002/anie.201803426

Reference yield:

1-methylhex-5-enylamine (196208-23-8) → 2.6-dimethylpiperidine (504-03-0)

Guidance literature:

With (CH₂)2[N(2,6-diethylphenyl)]2 yttrium(III)N(trimethylsilyl)2; at 120 ℃;

DOI:10.1002/1521-3773(20021004)41:19<3645::AID-ANIE3645>3.0.CO;2-F

Reference yield:

2,6-heptandione (13505-34-5) → 2.6-dimethylpiperidine (504-03-0)

Guidance literature:

With potassium hydroxide; sodium cyanoborohydride; ammonium bromide; In methanol; at 20 ℃; Yield given;

DOI:10.1016/S0040-4020(01)85010-9

upstream raw materials:

N-nitroso-2,6-dimethylpiperidine

2,6-heptandione

N-chloro-2,6-dimethylpiperidine

toluene-4-sulfonamide

Downstream raw materials:

3-<2,6-Dimethyl-piperidinomethyl>-rifamycin SV

2-(2,6-dimethylpiperidinyl)ethanol

1-phenyl-2-(2,6-dimethylpiperidinyl)ethanol

(2,6-Dimethyl-piperidin-1-yl)-(2-hydroxymethyl-phenyl)-methanone

Refernces

• 1、 Clarke, Joshua J.,Maekawa, Yuuki,Nambo, Masakazu,Crudden, Cathleen M.. "Borenium-Catalyzed Reduction of Pyridines through the Combined Action of Hydrogen and Hydrosilane". supporting information. p. 6617 - 6621. Retrieved 2021/09/02.
• 2、 Chen, Feng,Li, Wu,Sahoo, Basudev,Kreyenschulte, Carsten,Agostini, Giovanni,Lund, Henrik,Junge, Kathrin,Beller, Matthias. "Hydrogenation of Pyridines Using a Nitrogen-Modified Titania-Supported Cobalt Catalyst". supporting information. p. 14488 - 14492. Retrieved 2018/10/26.