PHOSPHORAMIDON

Base Information

• Chemical Name: PHOSPHORAMIDON
• CAS No.: 119942-99-3
• Molecular Formula: C23H32N3Na2O10P
• Molecular Weight: 566.4937
• Hs Code.: 2940000080
• Mol file: 119942-99-3.mol

Synonyms:L-Tryptophan,N-[N-[[(6-deoxy-a-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-,sodium salt;NSC 694280;

Chemical Property of PHOSPHORAMIDON

Chemical Property:

• PSA: 226.14000
• LogP: 0.11390
• Storage Temp.: −20°C
• Solubility.: H2O: 1 mM Stock solution stable for 1 month at –20&#

Purity/Quality:

98%,99%, ^*data from raw suppliers

Phosphoramidon disodium salt ≥95%(HPLC) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM.1?Also inhibits neprilysin 2 (Ki~2 nM).2?Also inhibits endothelin-converting enzyme (IC50?= 0.68 μM).3?Induces a dramatic increase in amyloid-beta levels in rodents.4
• Uses: An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury. Phosphoramidon is an inhibitor of NEP 24.11 and NEP2. It is an inhibitor of the enzyme thermolysin, a membrane metallo-endopeptidase inhibitor, and an endothelin converting enzyme inhibitor.