4-(3-Nitrophenylsulfonyl)morpholine

Base Information

• Chemical Name: 4-(3-Nitrophenylsulfonyl)morpholine
• CAS No.: 91619-33-9
• Molecular Formula: C10H12 N2 O5 S
• Molecular Weight: 272.282
• Hs Code.: 2934999090
• NSC Number: 41055
• DSSTox Substance ID: DTXSID90285208
• Wikidata: Q82020501
• Mol file: 91619-33-9.mol

Synonyms:91619-33-9;4-(3-NITROPHENYLSULFONYL)MORPHOLINE;4-((3-Nitrophenyl)sulfonyl)morpholine;4-(3-nitrophenyl)sulfonylmorpholine;4-(3-Nitro-benzenesulfonyl)-morpholine;4-[(3-Nitrophenyl)sulfonyl]morpholine;4-(3-NITROBENZENESULFONYL)MORPHOLINE;NSC41055;CBMicro_008083;SCHEMBL4982309;DTXSID90285208;SMSF0014198;MFCD00622715;NSC 41055;NSC-41055;STK219681;AKOS000727595;AB06557;CB10627;4-(3-Nitrobenzene-1-sulfonyl)morpholine;4-[(3-Nitrophenyl)sulfonyl]morpholine #;LS-07273;BIM-0008034.P001;CS-0206278;EU-0084027;FT-0728218;SR-01000508672;SR-01000508672-1;Z45515788;METHYL3-(3-BROMO-4-HYDROXY-5-METHOXYPHENYL)-2-CYANOACRYLATE

Chemical Property of 4-(3-Nitrophenylsulfonyl)morpholine

Chemical Property:

• Vapor Pressure: 2.54E-08mmHg at 25°C
• Boiling Point: 450.9°Cat760mmHg
• Flash Point: 226.5°C
• PSA: 100.81000
• Density: 1.45g/cm³
• LogP: 2.15760
• Storage Temp.: 2-8°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 272.04669266
• Heavy Atom Count: 18
• Complexity: 394

Purity/Quality:

98%min ^*data from raw suppliers

4-(3-Nitrophenylsulfonyl)morpholine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1S(=O)(=O)C2=CC=CC(=C2)[N+](=O)[O-]

Technology Process of 4-(3-Nitrophenylsulfonyl)morpholine

There total 3 articles about 4-(3-Nitrophenylsulfonyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

morpholine (110-91-8,99108-56-2) + 3-nitrobenzenesulphonyl chloride (121-51-7) → 4-(3-nitrophenylsulfonyl)morpholine (91619-33-9)

Guidance literature:

With triethylamine; In dichloromethane; for 2h;

DOI:10.1002/ardp.200700125

Reference yield:

morpholine (110-91-8,99108-56-2) + 3-nitrobenzenesulphonyl chloride (121-51-7) + cyclopropanemethylamine (2516-47-4) → 4-(3-nitrophenylsulfonyl)morpholine (91619-33-9)

Guidance literature:

morpholine; cyclopropanemethylamine; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

3-nitrobenzenesulphonyl chloride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

→ 4-(3-nitrophenylsulfonyl)morpholine (91619-33-9)

Guidance literature:

Morpholin, 3-Nitro-benzol-sulfonylchlorid, Dioxan, Triaethylamin;

upstream raw materials:

morpholine

3-nitrobenzenesulphonyl chloride

cyclopropanemethylamine

Downstream raw materials:

C₁₈H₁₈N₄O₄S

4-(3-aminophenylsulfonyl)morpholine

Refernces

• 1、 Chaulet, Charlotte,Croix, Cécile,Alagille, David,Normand, Sylvain,Delwail, Adriana,Favot, Laure,Lecron, Jean-Claude,Viaud-Massuard, Marie-Claude. "Design, synthesis and biological evaluation of new thalidomide analogues as TNF-α and IL-6 production inhibitors". scheme or table. p. 1019 - 1022. Retrieved 2011/03/21.
• 2、 Qandil, Amjad M.,Hassan, Mohammad A.,Al-Shar'i, Nizar A.. "Synthesis and anticandidal activity of azole-containing sulfonamides". experimental part. p. 99 - 112. Retrieved 2009/04/03.