Phenoxybenzamine hydrochloride

Base Information

• Chemical Name: Phenoxybenzamine hydrochloride
• CAS No.: 63-92-3
• Molecular Formula: C18H22 Cl N O . Cl H
• Molecular Weight: 340.293
• Hs Code.: 2922299090
• European Community (EC) Number: 200-569-7
• NSC Number: 759572,37448
• UNII: X1IEG24OHL
• DSSTox Substance ID: DTXSID0021127
• Wikidata: Q27107723
• NCI Thesaurus Code: C44435
• RXCUI: 71512
• ChEMBL ID: CHEMBL1200787
• Mol file: 63-92-3.mol

Synonyms:Dibenylene;Dibenyline;Dibenziran;Dibenzylin;Dibenzyline;Dibenzyran;Hydrochloride, Phenoxybenzamine;Phenoxybenzamine;Phenoxybenzamine Hydrochloride

Chemical Property of Phenoxybenzamine hydrochloride

Chemical Property:

• Appearance/Colour: White crystalline powder.
• Vapor Pressure: 5.07E-06mmHg at 25°C
• Melting Point: 137.5 ºC
• Boiling Point: 381.5 °C at 760 mmHg
• PKA: pKa 4.4 (Uncertain)
• Flash Point: 184.5 °C
• PSA: 12.47000
• LogP: 4.99690
• Storage Temp.: 2-8°C
• Solubility.: H2O: slightly soluble
• Water Solubility.: <0.01 g/100 mL at 18.5℃
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 8
• Exact Mass: 339.1156697
• Heavy Atom Count: 22
• Complexity: 262

Purity/Quality:

99% ^*data from raw suppliers

Phenoxybenzamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-40
• Safety Statements: 22-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl
• Recent EU Clinical Trials: Pheochromocytoma RandomisEd Study Comparing adRenoreceptor Inhibiting agents for Preoperative Treatment
• Description: Phenoxybenzamine hydrochloride (dibenzyline) is an orally effective, long-acting non-selective (alpha1 and alpha2) alpha-adrenoceptor blocking agent. It is used for the control of episodes of hypertension associated withpheochromocytoma. It literally produces a "chemical sympathectomy". It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. The initialdose is 10 mg/day, increased by 10 mg every 4 days till the desired response is attained.The usual dosage range is 20-60mg/day.
• Uses: Phenoxybenzamine is used in treating pheochromocytoma, swelling of the medullary layer of the adrenal glands, during which a large quantity of epinephrine is produced, which leads to a significant elevation of blood pressure. Phenoxybenzamine (5.0 to 60.0 mg/day) is used in order to control episodes of hypertension and sweating, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers. If tachycardia is excessive, it may also be necessary to use a betablocker concomitantly. In addition, phenoxybenzamine has been tested for its efficacy in micturition disorders resulting from neurogenic bladder, functional outlet obstruction, and partial prostatic obstruction.
• Clinical Use: Oral phenoxybenzamine is used for the preoperativemanagement of patients with pheochromocytoma and in thechronic management of patients whose tumors are notamenable to surgery. Only about 20% to 30% of an oraldose is absorbed.
• Drug interactions: Dibenzyline (phenoxybenzamine hydrochloride) may interact with compounds that stimulate both alpha- and beta-adrenergic receptors (i.e., epinephrine) to produce an exaggerated hypotensive response and tachycardia.

Technology Process of Phenoxybenzamine hydrochloride

There total 2 articles about Phenoxybenzamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(phenoxyisopropyl)-N-benzyl ethanolamine (101-45-1) → phenoxybenzamine hydrochloride (63-92-3,32378-29-3,5219-59-0)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 30 ℃; for 2h;

Reference yield:

→ phenoxybenzamine hydrochloride (63-92-3,32378-29-3,5219-59-0)

Guidance literature:

Reference yield:

phenoxybenzamine hydrochloride (63-92-3,32378-29-3,5219-59-0) → phenoxybenzamine hydrochloride di-zinc chloride

Guidance literature:

With zinc(II) chloride; at 60 - 80 ℃; for 24h; Inert atmosphere; Sealed tube;

upstream raw materials:

N-(phenoxyisopropyl)-N-benzyl ethanolamine

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING SALT SENSITIVITY OF BLOOD PRESSURE". . . Retrieved 2015/02/05.