Diphosphofructose;Esafosfan;FDP

Base Information

• Chemical Name: Diphosphofructose;Esafosfan;FDP
• CAS No.: 488-69-7
• Deprecated CAS: 125740-83-2,4004-40-4,77-82-7
• Molecular Formula: C6H14O12P2
• Molecular Weight: 340.117
• Hs Code.: 2940000000
• European Community (EC) Number: 207-683-6
• Wikipedia: Fructose_1,6-bisphosphate
• Mol file: 488-69-7.mol

Synonyms:Diphosphofructose;Esafosfan;FDP;488-69-7;tetrasodium;[(2R,3S,4S,5R)-2,3,4-trihydroxy-5-(phosphonatooxymethyl)oxolan-2-yl]methyl phosphate;hydrate

Chemical Property of Diphosphofructose;Esafosfan;FDP

Chemical Property:

• Vapor Pressure: 5.52E-23mmHg at 25°C
• Refractive Index: 1.585
• Boiling Point: 722.6 °C at 760 mmHg
• PKA: 1?+-.0.10(Predicted)
• Flash Point: 390.8 °C
• PSA: 223.06000
• Density: 2.095 g/cm³
• LogP: -2.98580
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 4
• Exact Mass: 445.93439156
• Heavy Atom Count: 25
• Complexity: 405

Purity/Quality:

99%, ^*data from raw suppliers

D-Fructose1,6-Bisphosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C(C(C(O1)(COP(=O)([O-])[O-])O)O)O)OP(=O)([O-])[O-].O.[Na+].[Na+].[Na+].[Na+]
• Isomeric SMILES: C([C@@H]1[C@H]([C@@H]([C@](O1)(COP(=O)([O-])[O-])O)O)O)OP(=O)([O-])[O-].O.[Na+].[Na+].[Na+].[Na+]
• Uses: Cardioprotectant for ischemic disorders.

Technology Process of Diphosphofructose;Esafosfan;FDP

There total 12 articles about Diphosphofructose;Esafosfan;FDP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

L-Glycerin-3-phosphat + (R)-glyceraldehyde 3-phosphate → D-Fructose-1,6-bisphosphat (488-69-7)

Guidance literature:

With oxygen; In water; glycerine phosphate oxidase 70 U, catalase 1000 U, D-fructose-1,6-bisphosphate aldolase;

Reference yield:

dihydroxyacetone phosphate (57-04-5) → fructose-1,6-bisphosphate (488-69-7,55529-38-9,87932-52-3)

Guidance literature:

dihydroxyacetone phosphate; With triosephosphate isomerase; Enzymatic reaction;

With Escherichia coli K-12 aldolase YdjI; In aq. buffer; for 24h; pH=8; Enzymatic reaction;

DOI:10.1021/acs.biochem.9b00326

Reference yield:

Sucrose (57-50-1) → fructose-1,6-bisphosphate (488-69-7,55529-38-9,87932-52-3)

Guidance literature:

With disodium phosphate; mit Hilfe von Bier-Hefe;

upstream raw materials:

fructose

D-glucose

L-altrose

glucose

Downstream raw materials:

D-(-)-3-phosphoglyceric acid

6-deoxy-D-fructose-1-phosphate disodium salt

6-deoxy-L-xylo-hexulose

5-deoxy-D-fructose

Refernces

• 1、 Neuberg,Lustig. "-". . p. 2722. Retrieved 1942.
• 2、 Huddleston, Jamison P.,Thoden, James B.,Dopkins, Brandon J.,Narindoshvili, Tamari,Fose, Blair J.,Holden, Hazel M.,Raushel, Frank M.. "Structural and functional characterization of ydji, an aldolase of unknown specificity in escherichia coli K12". . p. 3340 - 3353. Retrieved 2019.
• 3、 Fessner, Wolf-Dieter,Eyrisch, Oliver. "Eintopfsynthese von Tagatose-1,6-bisphosphat durch diastereoselektive enzymatische Aldoladdition". . p. 76 - 78. Retrieved 2007/10/02.