Decadron-LA

Base Information Edit

Chemical Name:Decadron-LA
CAS No.:1177-87-3
Molecular Formula:C24H31FO6
Molecular Weight:434.505
Hs Code.:29372290
NSC Number:756721
Mol file:1177-87-3.mol

Synonyms:Dexamethasone-21-acetate;Decadron-LA;Fortecortin (VAN);EINECS 214-646-8;C24-H31-F-O6;Spectrum_000900;Dexamethasone21-acetate;Spectrum2_001031;Spectrum3_000380;Spectrum4_000501;Spectrum5_000835;BSPBio_002139;KBioGR_001041;KBioSS_001380;DivK1c_000865;SPECTRUM1500231;SPBio_001241;SCHEMBL10042826;HMS502L07;KBio1_000865;KBio2_001380;KBio2_003948;KBio2_006516;KBio3_001359;9-Fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione acetate;NINDS_000865;HMS1920E06;Pharmakon1600-01500231;Pregna-1,4-dieno-3,20-diona, 21-(acetiloxi)-9-fluoro-11,17-dihidroxi-16-metil-, (11 beta, 16 alfa)-;CCG-40195;NSC756721;NSC-756721;IDI1_000865;NCGC00178796-01;SBI-0051336.P003;D3628;AB00051964_02;SR-05000001601;SR-05000001601-1;BRD-A93424738-001-02-2;BRD-A93424738-001-03-0;9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methyl-1,4-pregnadiene-3,20-dione 21-Acetate

Suppliers and Price of Decadron-LA

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
21-O-AcetylDexamethasone
50mg
$ 45.00

Sigma-Aldrich
Dexamethasone 21-acetate VETRANAL
100mg
$ 71.90

Sigma-Aldrich
Dexamethasone 21-acetate ≥99%
100mg
$ 50.70

Sigma-Aldrich
Dexamethasone Acetate Pharmaceutical Secondary Standard; Certified Reference Material
1g
$ 92.70

Sigma-Aldrich
Dexamethasone 21-acetate ≥99%
500mg
$ 150.00

Sigma-Aldrich
Dexamethasone acetate European Pharmacopoeia (EP) Reference Standard
$ 183.00

Sigma-Aldrich
Dexamethasone acetate European Pharmacopoeia (EP) Reference Standard
d0710000
$ 183.00

Sigma-Aldrich
Dexamethasone acetate European Pharmacopoeia (EP) Reference Standard
2ea
$ 173.00

Sigma-Aldrich
Dexamethasone 21-acetate ≥99%
1g
$ 268.00

Sigma-Aldrich
Dexamethasone acetate United States Pharmacopeia (USP) Reference Standard
200mg
$ 366.00

Total 193 raw suppliers

Chemical Property of Decadron-LA Edit

Chemical Property:

Appearance/Colour:White or almost white crystalline powder
Vapor Pressure:7.75E-16mmHg at 25°C
Melting Point:238-240 ºC(lit.)
Refractive Index:87 ° (C=1, Dioxane)
Boiling Point:579.4 ºC at 760 mmHg
PKA:12.08±0.70(Predicted)
Flash Point:304.2 ºC
PSA：100.90000
Density:1.3 g/cm³
LogP:2.46650
Storage Temp.:2-8°C
Solubility.:Soluble at 100 mg/ml in acetone
Water Solubility.:13mg/L(25 oC)
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:434.21046687
Heavy Atom Count:31
Complexity:910

Purity/Quality:

99% ^*data from raw suppliers

21-O-AcetylDexamethasone ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 43
Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C
Isomeric SMILES:C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)F)C
Recent EU Clinical Trials:A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF AN OINTMENT FORMULATION CONTAINING DEXAMETHASONE IN PATIENTS WITH RHINOSINUSITIS
Uses Dexamethasone has many uses in the treatment of cancer. Dexamethasone relieves inflammation in various parts of the body. To treat or prevent allergic reactions. As treatment of certain kinds of autoimmune diseases, skin conditions, asthma and other lung conditions. As treatment for a variety of cancers, such as leukemia, lymphoma, and multiple myeloma. It is also used for replacement therapy in adrenal insufficiency and in a screening test for the diagnosis of cushing's syndrome. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice. Dexamethasone acetate is used as a pharmaceutical primary standard to quantify the analyte in pharmaceutical formulations using chromatography ttechniques. Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.
Therapeutic Function 9-Fluoro-11β,17-dihydroxy-21-acetoxy-16α-methylpregna1,4-diene-3,20-dione

Technology Process of Decadron-LA

There total 21 articles about Decadron-LA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.8%