2',4',5,7-tetramethoxymethoxyisoflavone

Base Information

• Chemical Name: 2',4',5,7-tetramethoxymethoxyisoflavone
• CAS No.: 1344028-49-4
• Molecular Formula: C₂₃H₂₆O₁₀
• Molecular Weight: 462.453
• Mol file: 1344028-49-4.mol

Synonyms:2',4',5,7-tetramethoxymethoxyisoflavone

Chemical Property of 2',4',5,7-tetramethoxymethoxyisoflavone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',4',5,7-tetramethoxymethoxyisoflavone

There total 5 articles about 2',4',5,7-tetramethoxymethoxyisoflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,4-bis(methoxymethoxy)phenylboronic acid (863578-46-5) + 3-iodo-5,7-bis(methoxymethoxy)-4H-1-benzopyran-4-one (1236208-90-4) → 2',4',5,7-tetramethoxymethoxyisoflavone (1344028-49-4)

Guidance literature:

With palladium 10% on activated carbon; sodium carbonate; In 1,2-dimethoxyethane; water; at 40 - 45 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2011.09.042

Reference yield:

1-iodo-2,4-dimethoxymethoxybenzene (1344028-46-1) → 2',4',5,7-tetramethoxymethoxyisoflavone (1344028-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 1 h / -100 - -78 °C / Inert atmosphere; Cooling with liquid nitrogen/methanol

2: ammonium chloride / tetrahydrofuran; diethyl ether; hexane / 1 h / 20 °C / Inert atmosphere; Saturated solution

3: palladium 10% on activated carbon; sodium carbonate / 1,2-dimethoxyethane; water / 40 - 45 °C / Inert atmosphere

With n-butyllithium; palladium 10% on activated carbon; sodium carbonate; ammonium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; hexane; water; 3: Suzuki-Miyaura coupling;

DOI:10.1016/j.tet.2011.09.042

Reference yield:

1,3-bis(methoxymethyl)resorcinol (57234-29-4) → 2',4',5,7-tetramethoxymethoxyisoflavone (1344028-49-4)

Guidance literature:

Multi-step reaction with 4 steps

1: iodine; silver(I) acetate / chloroform / 5 h / 20 °C / Inert atmosphere

2: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 1 h / -100 - -78 °C / Inert atmosphere; Cooling with liquid nitrogen/methanol

3: ammonium chloride / tetrahydrofuran; diethyl ether; hexane / 1 h / 20 °C / Inert atmosphere; Saturated solution

4: palladium 10% on activated carbon; sodium carbonate / 1,2-dimethoxyethane; water / 40 - 45 °C / Inert atmosphere

With n-butyllithium; palladium 10% on activated carbon; iodine; silver(I) acetate; sodium carbonate; ammonium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; hexane; chloroform; water; 4: Suzuki-Miyaura coupling;

DOI:10.1016/j.tet.2011.09.042

upstream raw materials:

2,4-bis(methoxymethoxy)phenylboronic acid

3-iodo-5,7-bis(methoxymethoxy)-4H-1-benzopyran-4-one

1-iodo-2,4-dimethoxymethoxybenzene

1,3-bis(methoxymethyl)resorcinol

Downstream raw materials:

2',4',5,7-tetrahydroxyisoflavone

Lupinalbin A

Refernces