2-(Dimethoxymethyl)tetrahydro-2,5-dimethoxyfuran

Base Information

• Chemical Name: 2-(Dimethoxymethyl)tetrahydro-2,5-dimethoxyfuran
• CAS No.: 65057-97-8
• Molecular Formula: C9H18 O5
• Molecular Weight: 206.239
• Hs Code.: 2932190090
• European Community (EC) Number: 265-329-6
• DSSTox Substance ID: DTXSID20983604
• Nikkaji Number: J69.818K
• Mol file: 65057-97-8.mol

Synonyms:65057-97-8;EINECS 265-329-6;2,5-Dimethoxy-2-(dimethoxymethyl)tetrahydrofuran;2-(Dimethoxymethyl)tetrahydro-2,5-dimethoxyfuran;Tetrahydro-2,5-dimethoxy-2-(dimethoxymethyl)furan;FURAN, TETRAHYDRO-2,5-DIMETHOXY-2-(DIMETHOXYMETHYL)-;2-(dimethoxymethyl)-2,5-dimethoxyoxolane;SCHEMBL7247972;DTXSID20983604;UYPVDAPQHYMIRL-UHFFFAOYSA-N;2,5-Dimethoxy-2-(dimethoxymethyl)oxolane;LS-70595;2,5-dimethoxy-2-dimethoxymethyltetrahydrofuran;2,5-dimethoxy-2-(1,1-dimethoxymethyl)tetrahydrofuran

Chemical Property of 2-(Dimethoxymethyl)tetrahydro-2,5-dimethoxyfuran

Chemical Property:

• Vapor Pressure: 0.0259mmHg at 25°C
• Boiling Point: 255.6°C at 760 mmHg
• Flash Point: 95.2°C
• PSA: 46.15000
• Density: 1.07g/cm³
• LogP: 0.73090
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 206.11542367
• Heavy Atom Count: 14
• Complexity: 171

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1CCC(O1)(C(OC)OC)OC

Technology Process of 2-(Dimethoxymethyl)tetrahydro-2,5-dimethoxyfuran

There total 7 articles about 2-(Dimethoxymethyl)tetrahydro-2,5-dimethoxyfuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,5-dihydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal (59906-91-1) → tetrahydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal (65057-97-8)

Guidance literature:

With hydrogen; nickel; In ethanol; for 2h; Ambient temperature;

DOI:10.1007/BF00762049

Reference yield:

2-(furan-2-yl)-1,3-dioxolane (1708-41-4) → tetrahydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal (65057-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 79.2 percent / NH₄Br / 3 h / -15 °C / electrolysis (current of 2.7 - 3.0 A at 12 - 14 V)

2: 89 percent / H₂ / Raney nickel / ethanol / 2 h / Ambient temperature

With hydrogen; ammonium bromide; nickel; In ethanol;

DOI:10.1007/BF00762049

Reference yield:

→ tetrahydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal (65057-97-8)

Guidance literature:

aus ungesaett. Acetal (8), H2 , Raney-Ni/MeOH;

upstream raw materials:

2,5-dihydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal

2-(furan-2-yl)-1,3-dioxolane

Downstream raw materials:

1-(3,4-dimethoxybenzyl)-1,2,3,4,5,12b-hexahydropyrrolo-[2',1':3,4]pyrazino[1,2-a][1,3]diazepin-7(8H)-one

1-benzyl-1,2,3,4,5,12b-hexahydropyrrolo[2',1':3,4]pyrazino[1,2-a][1,3]diazepin-7(8H)-one

3,3-dimethyl-1-(3,4-dimethoxybenzyl)-1,3,4,11b-tetrahydro-2H-pyrrolo[2',1':3,4]pyrazino[1,2-a]pyrimidin-6(7H)-one

1-(3,4-dimethoxybenzyl)-1,3,4,11b-tetrahydro-2H-pyrrolo-[2',1':3,4]-pyrazino[1,2-a]pyrimidin-6(7H)-one

Refernces

• 1、 Peresada, V. P.,Ostrovskaya, R. U.,Likhosherstov, A. M.,Rodionov, A. P.,Rozenberg, S. G.,Skoldinov, A. P.. "SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF SOME 2,5-DIALKOXY-2-(DIALKOXYMETHYL)TETRAHYDROFURANS". . p. 341 - 346. Retrieved 2007/10/02.