4-Isopropylphenylhydrazine hydrochloride

Base Information

• Chemical Name: 4-Isopropylphenylhydrazine hydrochloride
• CAS No.: 118427-29-5
• Molecular Formula: C9H14N2^.HCl
• Molecular Weight: 186.684
• Hs Code.: 29280000
• European Community (EC) Number: 626-619-1
• DSSTox Substance ID: DTXSID60369807
• Mol file: 118427-29-5.mol

Synonyms:118427-29-5;4-Isopropylphenylhydrazine hydrochloride;(4-Isopropylphenyl)hydrazine hydrochloride;4-Isopropylphenylhydrazine, HCl;4-Isopropylphenylhydrazine, Hydrochloride;(4-propan-2-ylphenyl)hydrazine;hydrochloride;MFCD00013461;4-Isopropylphenylhydrazine HCl;Hydrazine, [4-(1-methylethyl)phenyl]-, monohydrochloride;[4-(propan-2-yl)phenyl]hydrazine hydrochloride;4-Isopropylphenylhydrazinehydrochloride;SCHEMBL935860;DTXSID60369807;LMFPPUVGWDZXMB-UHFFFAOYSA-N;GEO-01623;AKOS005143665;GS-3171;p-isopropylphenylhydrazine hydrochloride;4-isopropylphenyl hydrazine hydrochloride;4-lsopropylphenylhydrazine phenylhydrazine;4-Isopropyl phenyl hydrazine hydrochloride;AC-22901;SY011417;(4-(i-propyl)phenyl]hydrazine hydrochloride;FT-0618848;4-Isopropylphenylhydrazine hydrochloride, 98%;EN300-247790;I10054;4-isopropylphenylhydrazine hydrochloric acid salt;J-501415;1-(4-isopropylphenyl)hydrazine hydrochloride;4-Isopropylphenylhydrazine Hydrochloride

Chemical Property of 4-Isopropylphenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0124mmHg at 25°C
• Melting Point: 203 °C (dec.)(lit.)
• Refractive Index: 1.584
• Boiling Point: 260.1 °C at 760 mmHg
• Flash Point: 128.1 °C
• PSA: 38.05000
• Density: 1.027g/cm³
• LogP: 3.67090
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 186.0923762
• Heavy Atom Count: 12
• Complexity: 104

Purity/Quality:

99% ^*data from raw suppliers

4-Isopropylphenylhydrazine, hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38-44
• Safety Statements: 26-37/39-36/37/39-22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1=CC=C(C=C1)NN.Cl
• Uses: 4-Isopropylphenylhydrazine hydrochloride may be used in the preparation of 4-isopropylphenylhydrazine, via neutralization with NaOH.

Technology Process of 4-Isopropylphenylhydrazine hydrochloride

There total 2 articles about 4-Isopropylphenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

4-Isopropylaniline (99-88-7) → (4-isopropylphenyl)hydrazine hydrochloride (118427-29-5)

Guidance literature:

4-Isopropylaniline; With hydrogenchloride; In water; for 0.166667h; Cooling with ice;

With sodium nitrite; In water; for 1h; Cooling with ice;

With hydrogenchloride; tin(ll) chloride; In water; for 3h; Cooling with ice;

Reference yield: 78.0%

4-iodocumene (17356-09-1) → (4-isopropylphenyl)hydrazine hydrochloride (118427-29-5)

Guidance literature:

4-iodocumene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 99.0%

chloroformic acid ethyl ester (541-41-3) + (4-isopropylphenyl)hydrazine hydrochloride (118427-29-5) → ethyl 2-(p-isopropylphenyl)hydrazinecarboxylate

Guidance literature:

With pyridine; In acetonitrile; at 0 ℃; for 1.25h;

DOI:10.1055/s-0037-1610105

upstream raw materials:

4-Isopropylaniline

4-iodocumene

Downstream raw materials:

N,N-Dimethyl-5-isopropyl-1H-indole-3-ethanamine

2-(4-Isopropyl-phenyl)-3-oxo-3,5-dihydro-2H-pyridazino[4,3-b]indole-4-carboxylic acid

2-(4-Isopropyl-phenyl)-3-oxo-3,5-dihydro-2H-pyridazino[4,3-b]indole-4-carboxylic acid ethyl ester

[1-(4-fluoro-benzyl)-5-isopropyl-2-methyl-1H-indol-3-yl]-acetic acid ethyl ester

Refernces

• 1、 Zhai, Min'an,Wang, Long,Liu, Shiyuan,Wang, Lijing,Yan, Peng,Wang, Junfang,Zhang, Jingbo,Guo, Haifei,Guan, Qi,Bao, Kai,Wu, Yingliang,Zhang, Weige. "Synthesis and biological evaluation of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors". . p. 137 - 147. Retrieved 2018/07/13.
• 2、 -. "A class of 1, 5 - diphenyl pyrazole - 3 - carboxylic acid compound and use thereof". Paragraph 0071; 0073. . Retrieved 2017/10/31.