4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone

Base Information

• Chemical Name: 4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone
• CAS No.: 608132-17-8
• Molecular Formula: C₂₁H₃₀N₂O₃S₂
• Molecular Weight: 422.613
• Mol file: 608132-17-8.mol

Synonyms:4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone

Chemical Property of 4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone

There total 2 articles about 4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-hydroxy-1,5-dihydropyrrolidone (608132-08-7) → 4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone (608132-17-8)

Guidance literature:

With ammonia; butyric acid; In toluene; at 120 ℃;

DOI:10.1248/cpb.c12-00791

Reference yield:

1,3-bis(tert-butylsulfanyl)propan-2-one → 4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone (608132-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 8 h / Reflux

1.2: 12 h / -5 - 20 °C

2.1: ammonia; butyric acid / toluene / 120 °C

With ammonia; toluene-4-sulfonic acid; butyric acid; In toluene;

DOI:10.1248/cpb.c12-00791

Reference yield: 95.0%

4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone (608132-17-8) → 4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-trifluoro acetamido-1,5-dihydropyrrolidone (608132-32-7)

Guidance literature:

With trifluoroacetic anhydride; In dichloromethane; at 20 ℃;

upstream raw materials:

4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-hydroxy-1,5-dihydropyrrolidone

Downstream raw materials:

4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-trifluoro acetamido-1,5-dihydropyrrolidone

N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide

6-amino-4-(2,4-dimethoxyphenyl)-4H-[1,2]dithioleheterocyclicpentene[4,3-b]-5-pyrrolidonecarboxylic acid ethyl ester

[4-(2,4-dimethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl]-carbamic acid allyl ester

Refernces

• 1、 -. "DITHIOLOPYRROLONE COMPOUNDS, THE PREPARATION AND THE USE THEREOF". Page/Page column 8. . Retrieved 2010/06/17.