SELEGILINE

Base Information Edit

Chemical Name:SELEGILINE
CAS No.:14611-51-9
Deprecated CAS:172964-89-5
Molecular Formula:C₁₃H₁₇N
Molecular Weight:187.285
Hs Code.:2921499090
European Community (EC) Number:604-507-3
UNII:2K1V7GP655
DSSTox Substance ID:DTXSID6023575
Nikkaji Number:J34.132K
Wikipedia:Selegiline
Wikidata:Q47495783
NCI Thesaurus Code:C61938
RXCUI:9639
Pharos Ligand ID:4ZNCJ37XW31H
Metabolomics Workbench ID:53426
ChEMBL ID:CHEMBL972
Mol file:14611-51-9.mol

Synonyms:Benzeneethanamine,N,a-dimethyl-N-2-propynyl-, (R)-;Benzeneethanamine, N,a-dimethyl-N-2-propynyl-, (aR)- (9CI);Phenethylamine, N,a-dimethyl-N-2-propynyl-, L-(-)- (8CI);(-)-Deprenil;(-)-Deprenyl;(-)-Selegiline;(R)-(-)-Deprenyl;(R)-Selegiline;Anipryl;Emsam TTS;L-Deprenyl;Selegiline;Selgene;Zelapar;

Suppliers and Price of SELEGILINE

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
R(-)-Selegiline solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
1 mL
$ 82.00

Sigma-Aldrich
R(-)-Selegiline solution 1.0mg/mL in methanol, ampule of 1mL, certified reference material
003-1ml
$ 82.00

Medical Isotopes, Inc.
R(-)-Selegiline[(-)-Deprenyl]
1 mg
$ 535.00

AvaChem
Selegiline
100mg
$ 119.00

AvaChem
Selegiline
25mg
$ 49.00

American Custom Chemicals Corporation
SELEGILINE 95.00%
1G
$ 770.10

Total 41 raw suppliers

Chemical Property of SELEGILINE Edit

Chemical Property:

Vapor Pressure:0.00606mmHg at 25°C
Melting Point:137.5-139 °C
Refractive Index:1.528
Boiling Point:272.5oC at 760 mmHg
PKA:7.53±0.50(Predicted)
Flash Point:108.4oC
PSA：3.24000
Density:0.954g/cm3
LogP:2.18260
Storage Temp.:?20°C
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:187.136099547
Heavy Atom Count:14
Complexity:195

Purity/Quality:

99.9% ^*data from raw suppliers

R(-)-Selegiline solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,T
Hazard Codes:F,T
Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antiparkinson Agents
Canonical SMILES:CC(CC1=CC=CC=C1)N(C)CC#C
Isomeric SMILES:C[C@H](CC1=CC=CC=C1)N(C)CC#C
Recent ClinicalTrials:Selegiline for the Treatment of Excessive Daytime Sleepiness in Parkinson's Disease
Recent EU Clinical Trials:The Effect of Rotigotine on Memory in Idiopathic Parkinson's Disease without Cognitive Impairment
Recent NIPH Clinical Trials:The DAT-SPECT study for the benefit of Selegilline or Zonisamide in Parkinson's Disease
Uses Antidyskinetic; antiparkinsonian (in combination with levodopa/carbidopa). This drug is a selective inhibitor of monoaminooxidase B, which suppresses dopamineinactivation processes and facilitates an increase of its level in the brain. In treating Parkinsonism, selegiline is usually used in combination with levodopa.
Biological Functions Another drug used in the treatment of Parkinson’s disease is selegiline (also known as deprenyl, or Eldepryl). It is an irreversible inhibitor of MAO-B, an important enzyme in the metabolism of dopamine (Fig. 33.2). Blockade of dopamine metabolism makes more dopamine available for stimulation of its receptors. Selegiline, as monotherapy, may be effective in the newly diagnosed patient with parkinsonism because its pharmacological effect enhances the actions of endogenous dopamine. Selegiline is also used in conjunction with levodopa– carbidopa in later-stage parkinsonism to reduce levodopa dosage requirements and to minimize or delay the onset of dyskinesias and motor fluctuations that usually accompany long-term treatment with levodopa. It has also been proposed that selegiline may slow the progression of the disease by reducing the formation of toxic free radicals produced during the metabolism of dopamine. However, any neuroprotective effect of selegiline in parkinsonian patients remains to be established. Most of the adverse reactions to selegiline are related to actions of increased levels of dopamine, as discussed earlier. At recommended doses, and unlike the nonselective MAO inhibitors used in the treatment of depression, selegiline has little effect on MAO-A and therefore generally does not cause the hypertension associated with the ingestion of tyramine-enriched foods. However, at doses higher than those usually recommended, MAO-A may be inhibited, which increases the risk of a tyramine reaction. Selegiline should not be coadministered with tricyclic antidepressants or selective serotonin uptake inhibitors because of the possibility of a severe adverse drug reaction (e.g., hyperpyrexia, agitation, delirium, coma).

Technology Process of SELEGILINE

There total 41 articles about SELEGILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 14611-52-0,2079-54-1
(R)-(-)-deprenyl hydrochloride

: 2323-36-6,4528-51-2,4530-70-5,14611-51-9
SELEGILINE

Guidance literature:: With sodium carbonate; for 1h;
DOI:10.1016/j.ijpharm.2011.01.015

Reference yield: 85.0%

: 826-10-8,4298-16-2
(R)-2-N-methylamino-1-phenylpropane hydrochloride

: 106-96-7
propargyl bromide

: 2323-36-6,4528-51-2,4530-70-5,14611-51-9
SELEGILINE

Guidance literature:: With potassium carbonate; In toluene; acetonitrile; at 20 ℃; for 3h; enantioselective reaction;
DOI:10.1016/j.tetlet.2015.10.010