pachypodol

Base Information

• Chemical Name: pachypodol
• CAS No.: 33708-72-4
• Molecular Formula: C18H16 O7
• Molecular Weight: 344.321
• Hs Code.: 2914509090
• Mol file: 33708-72-4.mol

Synonyms:Flavone,4',5-dihydroxy-3,3',7-trimethoxy- (7CI,8CI); 3,3',7-Trimethylquercetin; 5,4'-Dihydroxy-3,7,3'-trimethoxyflavone;CMF 1; Isorhamnetin 3,7-dimethyl ether; NSC 168805; Pachypodol; Quercetin3,3',7-trimethyl ether; Quercetin-3,7,3'-trimethyl ether; Ro 09-0179

Chemical Property of pachypodol

Chemical Property:

• Vapor Pressure: 6.22E-15mmHg at 25°C
• Boiling Point: 598.8°Cat760mmHg
• Flash Point: 220.7°C
• PSA: 98.36000
• Density: 1.45g/cm³
• LogP: 2.89700

Purity/Quality:

≥98% ^*data from raw suppliers

Pachypodol phyproof? Reference Substance ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of pachypodol

There total 8 articles about pachypodol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(4-benzyloxy-3-methoxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one (77813-31-1) → ayanin (33708-72-4)

Guidance literature:

In palladium-charcoal; ethanol;

Reference yield: 54.4%

diazomethane (186581-53-3,908094-01-9,334-88-3) + quercetol (117-39-5,74893-81-5) → ayanin (33708-72-4) + ayanin (572-32-7) + retusin (1245-15-4)

Guidance literature:

In 1,4-dioxane; at 0 - 22 ℃;

DOI:10.1007/s10600-020-03164-2

Reference yield: 30.0%

quercetol (117-39-5,74893-81-5) + methyl iodide (74-88-4) → quercetin 3,3',4'-trimethyl ether (14549-84-9) + 2-(3,4-dimethoxyphenyl)-3,7-dihydroxy-5-methoxy-4H-chromen-4-one (3306-16-9) + ayanin (33708-72-4) + ayanin (572-32-7) + retusin (1245-15-4) + 3-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (93876-67-6) + 2-(3,4-dimethoxyphenyl)-3,5-dihydroxy-7-methoxy-4H-chromen-4-one (6068-80-0)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 3h;

DOI:10.1007/s00044-019-02412-7

upstream raw materials:

1-(2,6-dihydroxy-4-methoxy-phenyl)-2-methoxy-ethanone

4-benzoyloxy-3-methoxy-benzoic acid-anhydride

quercetol

dimethyl sulfate

Downstream raw materials:

quercetin 5,4′-di-O-acetyl-3,7,3′-tri-O-methyl ether

Refernces

• 1、 Karimova,Baltina,Spirikhin,Sapozhnikova,Gabdrakhmanova,Makara. "Methylation of Quercetin by Diazomethane and Hypoglycemic Activity of its Tetra-O-Methyl Ether". . p. 837 - 841. Retrieved 2020/09/18.
• 2、 Briggs, Malcolm T.,Duncan, Graham L. S.,Thornber, Craig W.. "The Preparation of Flavones and their Derivatives. Part I. Flavones and 4-Thioflavones.". . p. 2461 - 2487. Retrieved 2007/10/02.