5,7,3',4'-O-tetramethylrutin

Base Information

• Chemical Name: 5,7,3',4'-O-tetramethylrutin
• CAS No.: 58528-03-3
• Molecular Formula: C₃₁H₃₈O₁₆
• Molecular Weight: 666.633
• Mol file: 58528-03-3.mol

Synonyms:5,7,3',4'-O-tetramethylrutin

Chemical Property of 5,7,3',4'-O-tetramethylrutin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7,3',4'-O-tetramethylrutin

There total 3 articles about 5,7,3',4'-O-tetramethylrutin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl sulfate (77-78-1) + rutin (153-18-4) → 5,7,3',4'-O-tetramethylrutin (58528-03-3)

Guidance literature:

With potassium carbonate; In acetone; for 80h; Reflux;

DOI:10.1016/j.phytochem.2009.06.003

Reference yield:

rutin (153-18-4) + methyl iodide (74-88-4) → 5,7,3',4'-O-tetramethylrutin (58528-03-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2012.05.026

Reference yield:

→ Permethyl-tamarixetin-glucosid (58528-03-3)

Guidance literature:

aus 4-OMe-glucosid (I), Dimethylsulfat;

upstream raw materials:

dimethyl sulfate

rutin

methyl iodide

Downstream raw materials:

2-(3,4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy-4H-4-chromenone

2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3-((3,4,5-trimethoxybenzyl)oxy)-4H-chromen-4-one

2-(3,4-dimethoxyphenyl)-3-(2-(3,4-dimethoxyphenyl)-2-oxoethoxy)-5,7-dimethoxy-4H-chromen-4-one

(E)-2-((2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4-oxo-4H-chromen-3-yl)oxy)-ethyl 3-(3,4,5-trimethoxyphenyl)acrylate

Refernces

• 1、 Rajaram, Pravien,Jiang, Ziran,Chen, Guanglin,Rivera, Alyssa,Phasakda, Alison,Zhang, Qiang,Zheng, Shilong,Wang, Guangdi,Chen, Qiao-Hong. "Nitrogen-containing derivatives of O-tetramethylquercetin: Synthesis and biological profiles in prostate cancer cell models". . p. 227 - 239. Retrieved 2019/03/23.
• 2、 Rasheed, Arun,Lathika,Raju, Y. Prasanna,Mansoor,Azeem,Balan, Nija. "Synthesis and pharmacological evaluation of mutual prodrugs of aceclofenac with quercetin, vanillin and l-tryptophan as gastrosparing NSAIDS". . p. 70 - 82. Retrieved 2016/01/25.