Ethyl aminoxyacetate hydrochloride

Base Information

• Chemical Name: Ethyl aminoxyacetate hydrochloride
• CAS No.: 3919-73-1
• Molecular Formula: C4H9NO3
• Molecular Weight: 155.581
• DSSTox Substance ID: DTXSID60959969
• NSC Number: 45077,12903
• Mol file: 3919-73-1.mol

Synonyms:ethyl 2-(aminooxy)acetate hydrochloride;Ethyl aminoxyacetate hydrochloride;WLN: ZO1VO2 &GH;SCHEMBL6095588;DTXSID60959969;IKCYQNSSQXAQHC-UHFFFAOYSA-N;NSC12903;NSC45077;ethyl (aminooxy)acetate hydrochloride;Ethyl 2-aminooxyacetate hydrochloride;NSC-12903;NSC-45077;EN300-27737267;Ethyl (aminooxy)acetate--hydrogen chloride (1/1)

Chemical Property of Ethyl aminoxyacetate hydrochloride

Chemical Property:

• Vapor Pressure: 0.456mmHg at 25°C
• Boiling Point: 193.8°Cat760mmHg
• Flash Point: 88.1°C
• PSA: 61.55000
• Density: g/cm³
• LogP: 0.94210
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 155.0349209
• Heavy Atom Count: 9
• Complexity: 73.7

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)CON.Cl

Technology Process of Ethyl aminoxyacetate hydrochloride

There total 3 articles about Ethyl aminoxyacetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(aminooxy)acetic acid hemihydrochloride + ethanol (64-17-5) → O-Ethoxycarbonylmethylhydroxylamine hydrochloride (3919-73-1)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol203213f

Reference yield: 91.0%

ethyl bromoacetate (105-36-2) → O-Ethoxycarbonylmethylhydroxylamine hydrochloride (3919-73-1)

Guidance literature:

Reference yield: 76.0%

N-(ethoxy carbonyl methoxy)-phthalimide (5251-81-0) → O-Ethoxycarbonylmethylhydroxylamine hydrochloride (3919-73-1)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 24h;

DOI:10.1021/jm030219z

upstream raw materials:

N-(ethoxy carbonyl methoxy)-phthalimide

ethyl bromoacetate

ethanol

Downstream raw materials:

3-(2-chloro-phenyl)-4H-[1,2,4]oxadiazin-5-one

pyridine hydrochloride

[5-Methanesulfonylamino-6-phenoxy-indan-(1E)-ylideneaminooxy]-acetic acid ethyl ester

O-(Benzyloxycarbonyl-D,L-phenylalanylamino)-hydroxy-essigsaeure-ethylester

Refernces

• 1、 Elokdah, Hassan,Sulkowski, Theodore S.,Abou-Gharbia, Magid,Butera, John A.,Chai, Sie-Yearl,McFarlane, Geraldine R.,McKean, Mar-Lee,Babiak, John L.,Adelman, Steven J.,Quinet, Elaine M.. "Design, Synthesis, and Biological Evaluation of Thio-Containing Compounds with Serum HDL-Cholesterol-Elevating Properties". . p. 681 - 695. Retrieved 2007/10/03.