CAY10683 (SantacruzaMate A)

Base Information

• Chemical Name: CAY10683 (SantacruzaMate A)
• CAS No.: 1477949-42-0
• Molecular Formula: C15H22N2O3
• Molecular Weight: 278.35
• Mol file: 1477949-42-0.mol

Synonyms:CAY10683 (SantacruzaMate A);N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid ethyl ester;Santacruzamate A (CAY10683);SantacruzaMate A;CAY10683;CAY1083

Chemical Property of CAY10683 (SantacruzaMate A)

Chemical Property:

• Boiling Point: 508.1±43.0 °C(Predicted)
• PKA: 12.68±0.46(Predicted)
• PSA: 67.43000
• Density: 1.087±0.06 g/cm3(Predicted)
• LogP: 2.65340
• Storage Temp.: -20°
• Solubility.: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).

Purity/Quality:

98% min ^*data from raw suppliers

SantacruzamateA ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4
• Uses: Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.

Technology Process of CAY10683 (SantacruzaMate A)

There total 1 articles about CAY10683 (SantacruzaMate A) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-[(ethoxycarbonyl)amino]butanoic acid (4143-09-3) + phenethylamine (64-04-0) → santacruzamate A (1477949-42-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/np400198r

upstream raw materials:

4-[(ethoxycarbonyl)amino]butanoic acid

phenethylamine

Refernces

• 1、 Liu, Qi,Lu, Wenhua,Ma, Mingzhe,Liao, Jianwei,Ganesan,Hu, Yumin,Wen, Shijun,Huang, Peng. "Synthesis and biological evaluation of santacruzamate A and analogs as potential anticancer agents". . p. 1109 - 1112. Retrieved 2015/02/05.
• 2、 Pavlik, Christopher M.,Wong, Christina Y. B.,Ononye, Sophia,Lopez, Dioxelis D.,Engene, Niclas,McPhail, Kerry L.,Gerwick, William H.,Balunas, Marcy J.. "Santacruzamate A, a potent and selective histone deacetylase inhibitor from the panamanian marine cyanobacterium cf. symploca sp.". . p. 2026 - 2033. Retrieved 2014/01/06.