DL-LEUCIC ACID

Base Information

• Chemical Name: DL-LEUCIC ACID
• CAS No.: 10303-64-7
• Molecular Formula: C6H12O3
• Molecular Weight: 132.159
• Hs Code.: 2918199090
• Mol file: 10303-64-7.mol

Synonyms:DL-2-HYDROXYISOCAPROIC ACID (ALPHA);DL-2-HYDROXY-4-METHYLVALERIC ACID;DL-ALPHA-HYDROXYISOCAPROIC ACID;DL-LEUCIC ACID;2-HYDROXYISOCAPROIC ACID;2-HYDROXY-4-METHYLVALERIC ACID;DL-A-HYDROXYISOCAPROIC ACID;DL-2-Hydroxyisocaproic acid

Chemical Property of DL-LEUCIC ACID

Chemical Property:

• Vapor Pressure: 0.00324mmHg at 25°C
• Melting Point: 78-80 °C(lit.)
• Refractive Index: 1.4691 (estimate)
• Boiling Point: 251.3°C at 760 mmHg
• Flash Point: 120.1°C
• PSA: 57.53000
• Density: 1.0160 (rough estimate)
• LogP: 0.47800

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-LEUCIC ACID

There total 24 articles about DL-LEUCIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-hydroxy-3-methylbutanenitrile (15344-34-0) → 2-hydroxy-4-methylpentanoic acid (10303-64-7,498-36-2)

Guidance literature:

With sulfuric acid; water; at 130 - 135 ℃; for 6h; Reagent/catalyst; Temperature;

Reference yield:

4-methyl-2-oxopentanoic acid (816-66-0) → 2-hydroxy-4-methylpentanoic acid (10303-64-7,498-36-2) + LEUCINE (328-39-2,21675-61-6,25248-98-0,70-45-1)

Guidance literature:

With [Ir(III)Cp*(bpy)(OH₂)](SO₄); ammonium formate; In water; at 80 ℃; for 6h; pH=5.0;

DOI:10.1021/ja031633r

Reference yield:

(R)-leucine (328-38-1,21675-61-6,25248-98-0,70-45-1) → 2-hydroxy-4-methylpentanoic acid (10303-64-7,498-36-2)

Guidance literature:

With sodium nitrite; In sulfuric acid; water;

upstream raw materials:

L-leucine

3-amino-4-methylpentanoic acid

hydroxy-isobutyl-malonic acid

2-Hydroxy-4-methyl-pentansaeure-butylester

Downstream raw materials:

3-methylbutyric acid

2-hydroxy-3-methylbutanoic acid

acetic acid

acetone

Refernces

• 1、 Luyten, Marcel A.,Bur, Daniel,Wynn, Hla,Parris, Wendy,Glod, Marvin,et al.. "An Evaluation of the Substrate Specificity, and of Its Modification by Site-Directed Mutagenesis, of the Cloned L-Lactate Dehydrogenase from Bacillus stearothermophilus". . p. 6800 - 6804. Retrieved 1989.
• 2、 Kallwass, Helmut K. W.,Luyten, Marcel A.,Parris, Wendy,Gold, Marvin,Kay, Cyril M.,Bryan Jones. "Effects of Gln102Arg and Cys97Gly mutations on the structural specificity and stereospecificity of the L-lactate dehydrogenase from Bacillus stearothermophilus". . p. 4551 - 4557. Retrieved 1992.
• 3、 Yu, Haitao,Fang, Yun,Xia, Yongmei,Wu, Jing. "Decomposition of sodium trichloroacetate in the presence of quaternary ammonium under microwave irradiation: A convenient one-pot synthesis of α-hydroxy acids in water". . p. 2421 - 2426. Retrieved 2007/10/03.