morpholine

Base Information

• Chemical Name: morpholine
• CAS No.: 99108-56-2
• Molecular Formula: C₄H₉NO
• Molecular Weight: 87.1216
• Mol file: 99108-56-2.mol

Synonyms:

Chemical Property of morpholine

Chemical Property:

• PKA: 8.33(at 25℃)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of morpholine

There total 296 articles about morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(trimethylsilyl)morpholine (13368-42-8) + chloro-trimethyl-silane (75-77-4) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → morpholine (110-91-8,99108-56-2) + 4-cyclohexen-1-ylmorpholine (670-80-4) + Hexamethyldisiloxane (107-46-0) + 1-(Trimethylsilyloxy)cyclohexene (6651-36-1) + morpholin hydrochloride (10024-89-2)

Guidance literature:

In diethyl ether; at -30 ℃; for 2h; Product distribution; other substrate, temperature and time;

Reference yield:

Thiobenzmorpholid (2032-36-2) → morpholine (110-91-8,99108-56-2) + phenylmethanethiol (100-53-8)

Guidance literature:

With Hexanethiol; C₂₈H₄₁NOP₂Ru; hydrogen; In 1,4-dioxane; at 150 ℃; for 36h; under 30003 Torr; chemoselective reaction; Autoclave;

DOI:10.1021/jacs.0c10884

Reference yield:

4-benzoylmorpholine (1468-28-6) → morpholine (110-91-8,99108-56-2) + 4-benzyl-morpholine (10316-00-4) + benzyl alcohol (100-51-6,185532-71-2)

Guidance literature:

With tris(2,4-pentanedionato)ruthenium(III); ytterbium(III) trifluoromethanesulfonate nonohydrate; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine]; In 1,4-dioxane; at 150 ℃; for 60h; under 3750.38 Torr; Autoclave;

DOI:10.1039/c5sc04671h

upstream raw materials:

N,N-di(2-hydroxyethyl)hydrazine

4-(4-nitroso-phenyl)-morpholine

N,N-bis(2-phenoxyethyl)amine

N-tosyldiethanolamine

Downstream raw materials:

2-morpholino-1-[4]pyridyl-ethanone-phenylhydrazone

2-morpholino-1-[2]pyridyl-ethanone-phenylhydrazone

3-morpholino-1-phenyl-propan-1-one oxime

bis-[4-(2-morpholino-acetylamino)-phenyl]-sulfone

Refernces

• 1、 García-Domínguez, Andrés,Gonzalez, Jorge A.,Leach, Andrew G.,Lloyd-Jones, Guy C.,Nichol, Gary S.,Taylor, Nicholas P.. "A Lewis Base Nucleofugality Parameter, NFB, and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics". supporting information. . Retrieved 2022/01/04.
• 2、 Luo, Jie,Rauch, Michael,Avram, Liat,Ben-David, Yehoshoa,Milstein, David. "Catalytic Hydrogenation of Thioesters, Thiocarbamates, and Thioamides". supporting information. p. 21628 - 21633. Retrieved 2021/01/11.