Diisopropylammonium dichloroacetate

Base Information

• Chemical Name: Diisopropylammonium dichloroacetate
• CAS No.: 660-27-5
• Molecular Formula: C6H15N^.C2H2Cl2O2
• Molecular Weight: 230.134
• Hs Code.: 2921199090
• European Community (EC) Number: 211-538-2
• UNII: BA6QDP0R4E
• DSSTox Substance ID: DTXSID7060962
• Wikidata: Q27274565
• Mol file: 660-27-5.mol

Synonyms:di-isopropylamine dichloroacetate;diisopropylamine dichloroacetate;diisopropylammonium dichloroethanoate;DIPA;dipromonium

Chemical Property of Diisopropylammonium dichloroacetate

Chemical Property:

• Appearance/Colour: COA
• Vapor Pressure: 74mmHg at 25°C
• Melting Point: 295oC (dec.)(lit.)
• Boiling Point: 83.9 °C at 760 mmHg
• Flash Point: 132.8 °C
• PSA: 49.33000
• LogP: 2.65840
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 229.0636342
• Heavy Atom Count: 13
• Complexity: 94

Purity/Quality:

99% ^*data from raw suppliers

Diisopropylammonium dichloroacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)NC(C)C.C(C(=O)O)(Cl)Cl
• Description: Diisopropylammonium dichloroacetate is a hepatoprotective drug that improves the energy metabolism of hepatocytes, promotes the regeneration of injured hepatocytes, increases the rate of tissue cell respiration and oxygen respiration, and reduces the accumulation of fat in the liver. It is mainly used clinically for the treatment of fatty liver, intrahepatic cholestasis, and general liver dysfunction. It is also used in the treatment of acute and chronic hepatitis, hepatomegaly, and early cirrhosis.
• Uses: Diisopropylammonium dichloroacetate (DIPA) is known to produce a significant and prolonged hypoglycemic effect in alloxan-diabetic but not in normal rats.Diisopropylamine 2,2-Dichloroacetate is used in the treatment of antituberculosis drugs-induced liver injury.

Technology Process of Diisopropylammonium dichloroacetate

There total 2 articles about Diisopropylammonium dichloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dichloro-acetic acid (79-43-6) + diisopropylamine (108-18-9) → Cubisol (660-27-5)

Guidance literature:

at 20 ℃;

DOI:10.1016/j.chemosphere.2017.12.055

Reference yield:

→ Cubisol (660-27-5)

Guidance literature:

Diisopropylamin, Dichloressigsaeure;

upstream raw materials:

dichloro-acetic acid

diisopropylamine

Refernces

• 1、 Kruglikova-L'vova,Rekunova,Ushakova,Iurkevich. "The synthesis of diisopropylammonium dichloracetate and the study of its pharmacological properties". . p. 19 - 22. Retrieved 2007/10/05.