SR2516

Base Information

• Chemical Name: SR2516
• CAS No.: 1061353-68-1
• Molecular Formula: C25H26F3N5O3
• Molecular Weight: 501.508
• Mol file: 1061353-68-1.mol

Synonyms:PND 1186;PND1186;PND-1186;SR 2516;SR2516;SR-2516;VS-4718;PND-1186 (VS-4718)

Chemical Property of SR2516

Chemical Property:

• Boiling Point: 654.0±55.0 °C(Predicted)
• PKA: 14.58±0.46(Predicted)
• PSA: 87.75000
• Density: 1.334±0.06 g/cm3(Predicted)
• LogP: 5.39430
• Solubility.: ≥50.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Purity/Quality:

98% min ^*data from raw suppliers

PND-1186 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: PND-1186 is a FAK inihbitor which selectively promotes tumor cell apoptosis in 3D environments.

Technology Process of SR2516

There total 5 articles about SR2516 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

PND-1186 hydrochloride (1356154-94-3) → 2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzamide (1061353-68-1)

Guidance literature:

With potassium carbonate; In water; ethyl acetate; Product distribution / selectivity;

Reference yield: 72.5%

2-methoxy-4-morpholinoaniline dihydrochloride + 2-((2-chloro-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide (1061358-71-1) → 2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzamide (1061353-68-1)

Guidance literature:

In butan-1-ol; Inert atmosphere; Reflux;

Reference yield: 46.7%

2-methoxy-4-morpholinoaniline (209960-91-8) + 2-((2-chloro-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide (1061358-71-1) → 2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzamide (1061353-68-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 170 ℃; for 0.416667h; microwave irradiation;

upstream raw materials:

2-methoxy-4-morpholinoaniline

2-((2-chloro-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide

PND-1186 hydrochloride

2-Amino-N-methylbenzamid

Downstream raw materials:

PND-1186 hydrochloride

Refernces

• 1、 -. "ANILINOPYRIDINES AS INHIBITORS OF FAK". Page/Page column 27-28. . Retrieved 2009/10/18.