UNC 669

Base Information

• Chemical Name: UNC 669
• CAS No.: 1314241-44-5
• Molecular Formula: C15H20BrN3O
• Molecular Weight: 338.2428
• Mol file: 1314241-44-5.mol

Synonyms:UNC 669;(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone;UNC699;(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone UNC669;UNC669, >=98%;(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone

Chemical Property of UNC 669

Chemical Property:

• Boiling Point: 458.0±45.0 °C(Predicted)
• PKA: 9.78±0.20(Predicted)
• PSA: 36.44000
• Density: 1.424±0.06 g/cm3(Predicted)
• LogP: 2.42030
• Solubility.: insoluble in H2O; ≥52.4 mg/mL in EtOH with ultrasonic; ≥9.35 mg/mL in DMSO

Purity/Quality:

99%+, ^*data from raw suppliers

(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT).

Technology Process of UNC 669

There total 1 articles about UNC 669 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-bromo-3-pyridinecarboxylic acid (20826-04-4) + 4-(1-pyrrolidinyl)piperidine (5004-07-9) → S7373 (1314241-44-5)

Guidance literature:

5-bromo-3-pyridinecarboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

4-(1-pyrrolidinyl)piperidine; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

DOI:10.1002/cmdc.201900021

upstream raw materials:

5-bromo-3-pyridinecarboxylic acid

4-(1-pyrrolidinyl)piperidine

Refernces

• 1、 Herold, J. Martin,Wigle, Tim J.,Norris, Jacqueline L.,Lam, Robert,Korboukh, Victoria K.,Gao, Cen,Ingerman, Lindsey A.,Kireev, Dmitri B.,Senisterra, Guillermo,Vedadi, Masoud,Tripathy, Ashutosh,Brown, Peter J.,Arrowsmith, Cheryl H.,Jin, Jian,Janzen, William P.,Frye, Stephen V.. "Small-molecule ligands of methyl-lysine binding proteins". supporting information; experimental part. p. 2504 - 2511. Retrieved 2011/06/24.