2-Chloro-3-fluoro-5-nitropyridine

Base Information

• Chemical Name: 2-Chloro-3-fluoro-5-nitropyridine
• CAS No.: 1079179-12-6
• Molecular Formula: C5H2ClFN2O2
• Molecular Weight: 176.534
• Hs Code.: 2933399090
• Mol file: 1079179-12-6.mol

Synonyms:2-Chloro-3-fluoro-5-nitropyridine

Chemical Property of 2-Chloro-3-fluoro-5-nitropyridine

Chemical Property:

• Boiling Point: 247.0±35.0 °C(Predicted)
• PKA: -4.41±0.10(Predicted)
• PSA: 58.71000
• Density: 1.595±0.06 g/cm3(Predicted)
• LogP: 2.30550
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

2-Chloro-3-fluoro-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-fluoro-5-nitropyridine

There total 2 articles about 2-Chloro-3-fluoro-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-fluoro-2-hydroxy-5-nitropyridine (1033202-14-0) → 2-chloro-3-fluoro-5-nitro-pyridine (1079179-12-6)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; at 60 ℃; for 10h;

Reference yield:

3-fluoro-1,2-dihydropyridin-2-one (1547-29-1) → 2-chloro-3-fluoro-5-nitro-pyridine (1079179-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 3 h / 0 °C

2: phosphorus pentachloride / trichlorophosphate / 1 h / 60 °C

With phosphorus pentachloride; sulfuric acid; nitric acid; In trichlorophosphate;

DOI:10.1039/c5md00589b

Reference yield: 56.3%

4-methyl-3-(methyloxy)phenol (19217-50-6) + 2-chloro-3-fluoro-5-nitro-pyridine (1079179-12-6) → 3-fluoro-2-(3-methoxy-4-methyl-phenoxy)-5-nitro-pyridine

Guidance literature:

With potassium carbonate; In acetonitrile; at 85 ℃; for 16h; Inert atmosphere;

upstream raw materials:

3-fluoro-2-hydroxy-5-nitropyridine

3-fluoro-1,2-dihydropyridin-2-one

Downstream raw materials:

phenyl 5-fluoro-6-(2-(methylsulfonyl)ethyl)pyridin-3-ylcarbamate

1-((1-(3-chlorophenyl)-3-cyclopropyl-1H-pyrazol-5-yl)methyl)-3-(5-fluoro-6-(2-(methylsulfonyl)ethyl)pyridin-3-yl)urea

Refernces

• 1、 Tantry, Subramanyam J.,Shinde, Vikas,Balakrishnan, Gayathri,Markad, Shankar D.,Gupta, Amit K.,Bhat, Jyothi,Narayan, Ashwini,Raichurkar, Anandkumar,Jena, Lalit Kumar,Sharma, Sreevalli,Kumar, Naveen,Nanduri, Robert,Bharath, Sowmya,Reddy, Jitendar,Panduga, Vijender,Prabhakar,Kandaswamy, Karthikeyan,Kaur, Parvinder,Dinesh, Neela,Guptha, Supreeth,Saralaya, Ramanatha,Panda, Manoranjan,Rudrapatna, Suresh,Mallya, Meenakshi,Rubin, Harvey,Yano, Takahiro,Mdluili, Khisi,Cooper, Christopher B.,Balasubramanian,Sambandamurthy, Vasan K.,Ramachandran, Vasanthi,Shandil, Radha,Kavanagh, Stefan,Narayanan, Shridhar,Iyer, Pravin,Mukherjee, Kakoli,Hosagrahara, Vinayak P.,Solapure, Suresh,Hameed, P.Shahul,Ravishankar, Sudha. "Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway". supporting information. p. 1022 - 1032. Retrieved 2016/06/08.
• 2、 -. "SUBSTITUTED HETEROAROMATIC PYRAZOLE-CONTAINING CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS". Page/Page column 131. . Retrieved 2013/03/26.