Technology Process of Metopimazine Acid
There total 5 articles about Metopimazine Acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxone / water; N,N-dimethyl-formamide / 3 h / 20 - 30 °C
2.1: potassium hydroxide / acetone / 20 - 30 °C
2.2: 3 h / 20 - 60 °C
3.1: potassium carbonate / toluene; N,N-dimethyl-formamide / 8 h / 90 - 100 °C
4.1: hydrogenchloride; water / 10 h / 70 - 80 °C
With
hydrogenchloride; oxone; water; potassium carbonate; potassium hydroxide;
In
water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/acs.oprd.7b00052
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene / 1 h / 20 - 30 °C
2.1: oxone / water; N,N-dimethyl-formamide / 3 h / 20 - 30 °C
3.1: potassium hydroxide / acetone / 20 - 30 °C
3.2: 3 h / 20 - 60 °C
4.1: potassium carbonate / toluene; N,N-dimethyl-formamide / 8 h / 90 - 100 °C
5.1: hydrogenchloride; water / 10 h / 70 - 80 °C
With
hydrogenchloride; oxone; water; potassium carbonate; potassium hydroxide;
In
water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/acs.oprd.7b00052
