3,4-Dimethoxybenzoic anhydride

Base Information

• Chemical Name: 3,4-Dimethoxybenzoic anhydride
• CAS No.: 24824-54-2
• Molecular Formula: C18H18O7
• Molecular Weight: 346.337
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID00552579
• Nikkaji Number: J587.276F
• Wikidata: Q82432928
• Mol file: 24824-54-2.mol

Synonyms:3,4-dimethoxybenzoic anhydride;24824-54-2;3,4-DIMETHOXYBENZOIC ACID ANHYDRIDE;(3,4-dimethoxybenzoyl) 3,4-dimethoxybenzoate;veratric anhydride;3,4-dimethoxybenzoicanhydride;SCHEMBL3193863;DTXSID00552579;MFCD00017158;AKOS015963883;CS-0450320;S11318;(3, 4-dimethoxybenzoyl) 3, 4-dimethoxybenzoate;Benzoic acid, 3,4-dimethoxy-, 1,1'-anhydride;TRANS,TRANS-4-BUTYL-4-VINYL-BICYCLOHEXYL;A911882

Chemical Property of 3,4-Dimethoxybenzoic anhydride

Chemical Property:

• Melting Point: 122-124°C
• Boiling Point: 516.0±50.0 °C(Predicted)
• PSA: 80.29000
• Density: 1.224±0.06 g/cm3(Predicted)
• LogP: 2.71820
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 346.10525291
• Heavy Atom Count: 25
• Complexity: 413

Purity/Quality:

98%Min ^*data from raw suppliers

2-Aminobenzoic3,4-DimethoxybenzoicAnhydride ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(=O)OC(=O)C2=CC(=C(C=C2)OC)OC)OC

Technology Process of 3,4-Dimethoxybenzoic anhydride

There total 6 articles about 3,4-Dimethoxybenzoic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Veratric acid (93-07-2) → 3,4-dimethoxybenzoic anhydride (24824-54-2)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/jm040770b

Reference yield: 85.0%

3,4-dimethoxy-benzaldehyde (120-14-9) → 3,4-dimethoxybenzoic anhydride (24824-54-2)

Guidance literature:

With tert.-butylhydroperoxide; copper(l) chloride; In dimethyl sulfoxide; toluene; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.02.066

Reference yield: 83.0%

(3,4-dimethoxyphenyl)methanol (93-03-8) → 3,4-dimethoxybenzoic anhydride (24824-54-2)

Guidance literature:

With tert.-butylhydroperoxide; tetrabutyl phosphonium bromide; In water; chlorobenzene; at 80 ℃; for 3h; Sealed tube;

DOI:10.1055/s-0036-1590905

upstream raw materials:

Veratric acid

3,4-dimethoxybenzoic acid chloride

1,2-dihydro-2-methoxycarbonylisoquinoline-1-carbonitrile

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

3,3',4',5,6,7,8-heptamethoxyflavone

5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone

5,7-dihydroxy-3',4'-dimethoxy flavone

3',4',5,6,7-pentahydroxyflavone

Refernces

• 1、 Zhi, Peng,Xi, Zi-Wei,Wang, Dan-Yan,Wang, Wei,Liang, Xue-Zheng,Tao, Fei-Fei,Shen, Run-Pu,Shen, Yong-Miao. "Vilsmeier-Haack reagent mediated synthetic transformations with an immobilized iridium complex photoredox catalyst". . p. 709 - 717. Retrieved 2019/01/10.
• 2、 Kaur, Avneet,Pathak, Dharam P.,Sharma, Vidushi,Wakode, Sharad. "Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents". . p. 891 - 902. Retrieved 2018/01/22.