L-THREO-METHYLPHENIDATE HYDROCHLORIDE

Base Information

• Chemical Name: L-THREO-METHYLPHENIDATE HYDROCHLORIDE
• CAS No.: 40572-71-2
• Molecular Formula: C14H20ClNO2
• Molecular Weight: 233.31
• Hs Code.: 2933399090
• Mol file: 40572-71-2.mol

Synonyms:L-THREO-METHYLPHENIDATE HYDROCHLORIDE;L-Ritalin hydrochloride, (2S,2μS)-(-)-threo-Methyl α-phenyl-α-(2-piperidyl)acetate hydrochloride;(2S,2'S)-(-)-threo-Methyl α-Phenyl-α-(2-piperidyl)acetate Hydrochloride

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Chemical Property of L-THREO-METHYLPHENIDATE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 327.6±17.0 °C(Predicted)
• PKA: 9.51±0.10(Predicted)
• PSA: 38.33000
• Density: 1.070±0.06 g/cm3(Predicted)
• LogP: 3.21610

Purity/Quality:

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of L-THREO-METHYLPHENIDATE HYDROCHLORIDE

There total 76 articles about L-THREO-METHYLPHENIDATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methylphenidate hydrochloride (298-59-9,19262-68-1,23644-60-2,23655-65-4,29419-95-2,29419-96-3,29419-97-4,56502-30-8) → dl-threo-methylphenidate (113-45-1,20748-11-2,20748-12-3,40431-62-7,40431-63-8,40431-64-9,40572-71-2,52703-69-2,52760-39-1,132831-06-2)

Guidance literature:

With ammonium hydroxide; In water; pH=~ 9;

Reference yield: 75.0%

methyl threo-2-phenyl-2-(N-methoxycarbonyl-2'-piperidyl)acetate → dl-threo-methylphenidate (113-45-1,20748-11-2,20748-12-3,40431-62-7,40431-63-8,40431-64-9,40572-71-2,52703-69-2,52760-39-1,132831-06-2)

Guidance literature:

With trimethylsilyl iodide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ol9905046

Reference yield: 65.0%

methanol (67-56-1) + (Z)-3-Amino-7-methanesulfonyloxy-2-phenyl-hept-2-enoic acid methyl ester (460356-15-4) → dl-threo-methylphenidate (113-45-1,20748-11-2,20748-12-3,40431-62-7,40431-63-8,40431-64-9,40572-71-2,52703-69-2,52760-39-1,132831-06-2) + methyl (R*)-2-phenyl-2-((S*)-piperidin-2-yl)acetate (113-45-1,20748-11-2,20748-12-3,40431-62-7,40431-63-8,40431-64-9,40572-71-2,52703-69-2,52760-39-1,132831-06-2)

Guidance literature:

(Z)-3-Amino-7-methanesulfonyloxy-2-phenyl-hept-2-enoic acid methyl ester; With hydrogenchloride; bromocresol green; sodium cyanoborohydride; In methanol; pH=6;

With potassium hydroxide; Heating;

methanol; With thionyl chloride;

DOI:10.1016/S0223-5234(01)01230-2

upstream raw materials:

methanol

Ritalinic acid

METHYLPHENIDATE

methylphenidate hydrochloride

Refernces

• 1、 -. "Methylphenidate, right pai methyl ester preparation method, intermediate and preparation method". . . Retrieved 2019/04/30.
• 2、 -. "ABUSE DETERRENT AND ANTI-DOSE DUMPING PHARMACEUTICAL SALTS USEFUL FOR THE TREATMENT OF ATTENTION DEFICIT/HYPERACTIVITY DISORDER". Page/Page column 23. . Retrieved 2012/02/06.