Thiethylperazine

Base Information

• Chemical Name: Thiethylperazine
• CAS No.: 1420-55-9
• Molecular Formula: C22H29 N3 S2
• Molecular Weight: 399.624
• European Community (EC) Number: 214-648-9,215-819-0
• UNII: 8ETK1WAF6R
• DSSTox Substance ID: DTXSID1023651
• Nikkaji Number: J3.667F
• Wikipedia: Thiethylperazine
• Wikidata: Q372725
• NCI Thesaurus Code: C62081
• Pharos Ligand ID: SSCNGFB9L9GL
• Metabolomics Workbench ID: 42740
• ChEMBL ID: CHEMBL1378
• Mol file: 1420-55-9.mol

Synonyms:Norzine;Thiethylperazine;Thiethylperazine Malate;Thiethylperazine Maleate (2:1);Torecan

Chemical Property of Thiethylperazine

Chemical Property:

• Melting Point: 62-64°
• Refractive Index: 1.5605 (estimate)
• Boiling Point: 559.8°Cat760mmHg
• Flash Point: 292.4°C
• PSA: 60.32000
• Density: 1.24g/cm³
• LogP: 4.97960
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 399.18029028
• Heavy Atom Count: 27
• Complexity: 455

Purity/Quality:

98%min ^*data from raw suppliers

THIETHYLPERAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)C
• Recent EU Clinical Trials: An open-label, multicenter, controlled pharmaco-dynamic clinical trial to explore the Amyloid beta draining effect of Thiethylperazine (TEP) in subjects with early-to-mild dementia due to Alzheimer’s Disease in comparison to healthy volunteers
• Therapeutic Function: Antiemetic

Technology Process of Thiethylperazine

There total 5 articles about Thiethylperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethylmercapto-phenothiazine-10-carboxylic acid-[3-(4-methyl-piperazino)-propyl ester] (113649-38-0) → thiethylperazine (1420-55-9)

Guidance literature:

at 200 ℃;

DOI:10.1002/hlca.19580410420

Reference yield:

(3-ethylsulfanyl-phenyl)-phenyl-amine (68083-49-8) → thiethylperazine (1420-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; sulfur / 160 °C

2: NaOH; toluene

With sodium hydroxide; iodine; sulfur; toluene;

DOI:10.1002/hlca.19580410420

Reference yield:

3-(N-methylpiperazinyl)propyl chloride (104-16-5) + 2-(ethylthio)-10H-phenothiazine (46815-10-5) → thiethylperazine (1420-55-9)

Guidance literature:

With sodium hydroxide; toluene;

DOI:10.1002/hlca.19580410420

upstream raw materials:

3-(N-methylpiperazinyl)propyl chloride

2-(ethylthio)-10H-phenothiazine

2-ethylmercapto-phenothiazine-10-carboxylic acid-[3-(4-methyl-piperazino)-propyl ester]

(3-ethylsulfanyl-phenyl)-phenyl-amine

Refernces