7-DEAZA-2'-DEOXYINOSINE

Base Information

• Chemical Name: 7-DEAZA-2'-DEOXYINOSINE
• CAS No.: 97224-58-3
• Molecular Formula: C₁₁H₁₃N₃O₄
• Molecular Weight: 251.242
• Mol file: 97224-58-3.mol

Synonyms:7-DEAZA-2'-DEOXYINOSINE;2'-Deoxy-7-deazainosine;7-Deazadeoxyinosine

Chemical Property of 7-DEAZA-2'-DEOXYINOSINE

Chemical Property:

• PSA: 100.37000
• LogP: -0.63470

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Deaza-2''-deoxyinosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Deaza-2''-deoxyinosine is a nucleoside showing ambiguous base-?pairing properties against the four canonical DNA constituents.

Technology Process of 7-DEAZA-2'-DEOXYINOSINE

There total 4 articles about 7-DEAZA-2'-DEOXYINOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

7-(2'-Desoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-2-methylthio-4H-pyrrolo<2,3-d>pyrimidin-4-on (98891-38-4) → 7-deaza-2'-deoxyinosine (97224-58-3)

Guidance literature:

nickel; In N,N-dimethyl acetamide; for 0.75h; Heating;

Reference yield:

7-(2'-Desoxy-β-D-erythro-pentofuranosyl)-4-methoxy-2-methylthio-7H-pyrrolo<2,3-d>pyrimidin (98891-39-5) → 7-deaza-2'-deoxyinosine (97224-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / 2N NaOH / 2 h / Heating

2: 48 percent / Raney-nickel / N,N-dimethyl-acetamide / 0.75 h / Heating

With sodium hydroxide; nickel; In N,N-dimethyl acetamide;

Reference yield:

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) → 7-deaza-2'-deoxyinosine (97224-58-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) C₆H₅(CH₃)3N(+)Cl(-), 50percent NaOH, 2) 1M Na-methanolate / 1) CH₂Cl₂, 30 min, 2) CH₃OH, 12 h, r.t.

2: 82 percent / 2N NaOH / 2 h / Heating

3: 48 percent / Raney-nickel / N,N-dimethyl-acetamide / 0.75 h / Heating

With sodium hydroxide; phenyltrimethylammonium chloride; sodium methylate; nickel; In N,N-dimethyl acetamide;

upstream raw materials:

7-(2'-Desoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-2-methylthio-4H-pyrrolo<2,3-d>pyrimidin-4-on

7-(2'-Desoxy-β-D-erythro-pentofuranosyl)-4-methoxy-2-methylthio-7H-pyrrolo<2,3-d>pyrimidin

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine

Refernces