cannabispiran

Base Information

• Chemical Name: cannabispiran
• CAS No.: 61262-81-5
• Molecular Formula: C₁₅H₁₈O₃
• Molecular Weight: 246.306
• Hs Code.: 2914509090
• Mol file: 61262-81-5.mol

Synonyms:Cannabispiran;Cannabispirone

Chemical Property of cannabispiran

Chemical Property:

• Boiling Point: 438.0±45.0 °C(Predicted)
• PKA: 9.76±0.20(Predicted)
• Flash Point: 166.4oC
• PSA: 46.53000
• Density: 1.23±0.1 g/cm3(Predicted)
• LogP: 2.72790

Purity/Quality:

≥96% ^*data from raw suppliers

Cannabispiran 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Cannabispirone is a natural compound from Cannabis sativa.

Technology Process of cannabispiran

There total 22 articles about cannabispiran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(+/-)-cannabispirenone-A (76898-51-6) → cannabispirone (61262-81-5)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/0040-4039(80)80247-4

Reference yield: 85.0%

cannabispiradienone-A (71135-79-0) → cannabispirone (61262-81-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; Ambient temperature;

Reference yield:

5,7-dimethoxyindan-1-one (880-87-5) → cannabispirone (61262-81-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 84 percent / potassium t-butoxide / 2-methyl-propan-2-ol; 1,2-dimethoxy-ethane / 50 h / 20 °C

2: 84 percent / n-butyl-lithium, diethylamine / hexane; tetrahydrofuran; hexamethylphosphoric acid triamide

3: 1.) di-isobutylaluminium hydride, 2.) aqueous acetic acid / 1.) toluene, -78 deg C, 2.5 h, 2.) room temperature, 30 min

4: 98 percent / m-hydrochloric acid / tetrahydrofuran / 12 h

5: 92 percent / aqueous potassium hydroxide / methanol / 24 h / 20 °C

6: 85 percent / lithium 1,1-dimethylethanethiolate / hexamethylphosphoric acid triamide / 2 h / 70 °C

7: 51 mg / H₂ / 5percent Pd-C / ethyl acetate

With hydrogenchloride; lithium tert-butylsulfide; potassium hydroxide; n-butyllithium; diisobutylaluminum hydride; potassium tert-butylate; hydrogen; acetic acid; diethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; hexane; ethyl acetate; tert-butyl alcohol;

upstream raw materials:

methanol

(+/-)-cannabispirenone-A

cannabispiradienone-A

β-cannabispiranol

Downstream raw materials:

α-cannabispiranol

β-cannabispiranol

Refernces

• 1、 El-Feraly et al.. "". . p. 2373,2374, 2377. Retrieved 1977.
• 2、 Crombie, Leslie,Tuchinda, Patoomratana,Powell, Michael J.. "Total Synthesis of the Spirans of Cannabis: Cannabispiradienone, Cannabispirenone-A and -B, Cannabispirone, α- and β-Cannabispiranols and the Dihydrophenanthrene Cannithrene-1". . p. 1477 - 1484. Retrieved 2007/10/02.