MHY1485

Base Information

• Chemical Name: MHY1485
• CAS No.: 326914-06-1
• Molecular Formula: C17H21N7O4
• Molecular Weight: 387.39314
• Mol file: 326914-06-1.mol

Synonyms:MHY1485;4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine;4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

Chemical Property of MHY1485

Chemical Property:

• Melting Point: 256-259 °C
• Boiling Point: 643.3±65.0 °C(Predicted)
• PKA: 6.19±0.10(Predicted)
• PSA: 121.46000
• Density: 1.415±0.06 g/cm3(Predicted)
• LogP: 1.92280
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble2mg/mL, clear (warmed)

Purity/Quality:

98%,99%, ^*data from raw suppliers

MHY 1485 >95.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: MHY1485 is a cell-permeable activator of mTOR that has been shown to increase levels of cellular mTOR Ser2448 and downstream substrate 4E-BP Thr37/46 phosphorylation in rat liver Ac2F cells. It can induce cellular LC3-II accumulation in Ac2F cells and has been shown to inhibit autophagy by suppressing the fusion between autophagosomes and lysosomes.
• Uses: MHY1485 has been used:to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylationto inhibit autophagyas a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis

Technology Process of MHY1485

There total 4 articles about MHY1485 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-chloro-4,6-di-morpholin-4-yl-[1,3,5]triazine (7597-22-0) + 4-nitro-aniline (100-01-6,104810-17-5) → (4,6-dimorpholin-4-yl-[1,3,5]triazin-2-yl)(4-nitrophenyl)amine (326914-06-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 5h; Reflux;

DOI:10.1016/j.bmc.2020.115408

Reference yield: 58.0%

2-chloro-4,6-di-morpholin-4-yl-[1,3,5]triazine (7597-22-0) + 4-nitro-aniline (100-01-6,104810-17-5) → 4,6-bis(morpholin-4-yl)-2-hydroxy-1,3,5-triazine (19899-85-5) + (4,6-dimorpholin-4-yl-[1,3,5]triazin-2-yl)(4-nitrophenyl)amine (326914-06-1)

Guidance literature:

In acetic acid; for 1h; Heating;

DOI:10.1002/jhet.5570450446

Reference yield:

4-nitro-aniline (100-01-6,104810-17-5) → (4,6-dimorpholin-4-yl-[1,3,5]triazin-2-yl)(4-nitrophenyl)amine (326914-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / tetrahydrofuran / Heating

2: K₂CO₃ / tetrahydrofuran / Heating

With potassium carbonate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2004.11.052

upstream raw materials:

morpholine

4,6-dichloro-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

4-nitro-aniline

2-chloro-4,6-di-morpholin-4-yl-[1,3,5]triazine

Refernces

• 1、 Kolmakov, Kirill A.. "Selective modification of bifunctional heterocyclic compounds containing amino and thioamide groups in acetic acid medium". . p. 1215 - 1220. Retrieved 2008/12/20.