4-Bromo-3-fluoro-2-methylaniline

Base Information

• Chemical Name: 4-Bromo-3-fluoro-2-methylaniline
• CAS No.: 127408-03-1
• Molecular Formula: C7H7BrFN
• Molecular Weight: 204.042
• Hs Code.: 2921420090
• Mol file: 127408-03-1.mol

Synonyms:4-Bromo-3-fluoro-2-methylaniline;4-Bromo-3-fluoro-2-methyl-phenylamine

Chemical Property of 4-Bromo-3-fluoro-2-methylaniline

Chemical Property:

• Boiling Point: 244.5±35.0 °C(Predicted)
• PKA: 2.73±0.10(Predicted)
• PSA: 26.02000
• Density: 1.589±0.06 g/cm3(Predicted)
• LogP: 3.06000
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ,99.9%, ^*data from raw suppliers

4-Bromo-3-fluoro-2-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-3-fluoro-2-methylaniline

There total 1 articles about 4-Bromo-3-fluoro-2-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-fluoro-2-methylaniline (443-86-7) → 4-bromo-3-fluoro-2-methylbenzenamine (127408-03-1)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 10 ℃; for 2h; Temperature;

Reference yield: 82.0%

4-bromo-3-fluoro-2-methylbenzenamine (127408-03-1) + bis(pinacol)diborane (73183-34-3) → 3-fluoro-2-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,2-dimethoxyethane; at 90 ℃; for 18h; Inert atmosphere;

Reference yield: 74.0%

4-bromo-3-fluoro-2-methylbenzenamine (127408-03-1) → 5-bromo-4-fluoro-1H-indazole (1082041-85-7)

Guidance literature:

With acetic acid; sodium nitrite; at 10 - 25 ℃; for 4h;

DOI:10.1021/acsmedchemlett.0c00667

upstream raw materials:

3-fluoro-2-methylaniline

Downstream raw materials:

4-Amino-2-fluoro-3-methylbenzonitrile

5-bromo-4-fluoro-1H-indazole

4-fluoro-5-(2-trifluoromethylphenyl)-1H-indazole

Refernces

• 1、 -. "METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS". Paragraph 0731. . Retrieved 2020/02/14.
• 2、 -. "COMPOUNDS FOR USE IN THE TREATMENT OF FASCIOLIASIS". Page/Page column 29. . Retrieved 2020/02/22.