(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)Methyl Methanesulfonate

Base Information

• Chemical Name: (1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)Methyl Methanesulfonate
• CAS No.: 1032825-19-6
• Molecular Formula: C12H21N3O4S
• Molecular Weight: 303.382
• Hs Code.: 2934999090
• Mol file: 1032825-19-6.mol

Synonyms:(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)Methyl Methanesulfonate

Chemical Property of (1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)Methyl Methanesulfonate

Chemical Property:

• PSA: 93.91000
• LogP: 2.53140
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(1-(3-Isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methyl methanesulfonate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)Methyl Methanesulfonate

There total 4 articles about (1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)Methyl Methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methanol (1032824-92-2) + methanesulfonyl chloride (124-63-0) → (1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methyl methanesulfonate (1032825-19-6)

Guidance literature:

With triethylamine; In dichloromethane; at 5 ℃; for 1.5h;

Reference yield:

4-piperidinemethanol (6457-49-4) → (1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methyl methanesulfonate (1032825-19-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 2.17 h / 0 - 20 °C

2.1: zinc(II) chloride / ethanol / 2.25 h / 20 °C

2.2: 18 h / 50 °C

2.3: pH 7

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With sodium hydrogencarbonate; triethylamine; zinc(II) chloride; In ethanol; dichloromethane; water;

Reference yield:

4-(hydroxymethyl) piperidine-1-carbonitrile (1032824-91-1) → (1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methyl methanesulfonate (1032825-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc(II) chloride / ethanol / 2.25 h / 20 °C

1.2: 18 h / 50 °C

1.3: pH 7

2.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With triethylamine; zinc(II) chloride; In ethanol; dichloromethane;

upstream raw materials:

(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methanol

methanesulfonyl chloride

4-piperidinemethanol

4-(hydroxymethyl) piperidine-1-carbonitrile

Downstream raw materials:

2-[({1-[3-(1-Methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}methyl)oxy]-5-[4-(methylsulfonyl)phenyl]pyrazine

2-[2-fluoro-4-(methylthio)phenyl]-5-[({1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}methyl)oxy]pyrazine

5-[({1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}methyl)oxy]-2-[4-(methylthio)phenyl]pyridine

2-[2-fluoro-4-(methylthio)phenyl]-5-[({1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}methyl)oxy]pyridine

Refernces

• 1、 -. "CYCLOHEXENE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING METABOLIC DISEASE COMPRISING THE SAME AS ACTIVE INGREDIENT". Paragraph 651; 652; 653; 654; 659; 660; 661; 662. . Retrieved 2017/05/19.
• 2、 -. "BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS". Page/Page column 50. . Retrieved 2010/03/02.