Wittifuran X

Base Information

• Chemical Name: Wittifuran X
• CAS No.: 1309478-07-6
• Molecular Formula: C15H12O5
• Molecular Weight: 272.257
• Mol file: 1309478-07-6.mol

Synonyms:Wittifuran X;5-(6-Hydroxy-5-methoxy-2-benzofuranyl)-1,3-benzenediol

Chemical Property of Wittifuran X

Chemical Property:

• PSA: 83.06000
• LogP: 3.22520

Purity/Quality:

98%Min ^*data from raw suppliers

WittifuranX ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Wittifuran X

There total 3 articles about Wittifuran X which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-(3,5-dibenzyloxyphenyl)-5-methoxy-6-hydroxybenzofuran → 5-(6-hydroxy-5-methoxy-1-benzofuran-2-yl)benzene-1,3-diol (1309478-07-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 12h;

Reference yield:

5-((3,5-bis(benzyloxy)phenyl)ethynyl)-2-(hydroxymethyl)-4H-pyran-4-one → 5-(6-hydroxy-5-methoxy-1-benzofuran-2-yl)benzene-1,3-diol (1309478-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: indium(III) triflate / tetrahydrofuran / 12 h / 100 °C / Inert atmosphere; Schlenk technique

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h / Schlenk technique

With indium(III) triflate; carbon tetrabromide; palladium 10% on activated carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1002/anie.201915212

Reference yield:

5-((3,5-bis(benzyloxy)phenyl)ethynyl)-2-(bromomethyl)-4H-pyran-4-one → 5-(6-hydroxy-5-methoxy-1-benzofuran-2-yl)benzene-1,3-diol (1309478-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: indium(III) triflate / tetrahydrofuran / 12 h / 100 °C / Inert atmosphere; Schlenk technique

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h / Schlenk technique

With indium(III) triflate; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethyl acetate;

DOI:10.1002/anie.201915212

Refernces

• 1、 Cao, Tongxiang,Jiang, Huanfeng,Zhang, Ling,Zhu, Shifa. "Deconstructive Reorganization: De Novo Synthesis of Hydroxylated Benzofuran". supporting information. p. 4670 - 4677. Retrieved 2020/02/20.