(5-iodo-2-Methylphenyl)Methanol

Base Information

• Chemical Name: (5-iodo-2-Methylphenyl)Methanol
• CAS No.: 1260242-01-0
• Molecular Formula: C8H9IO
• Molecular Weight: 248.063
• Hs Code.: 2906290090
• Mol file: 1260242-01-0.mol

Synonyms:(5-iodo-2-Methylphenyl)Methanol;5-Iodo-2-methylbenzenemethanol

Chemical Property of (5-iodo-2-Methylphenyl)Methanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.09190
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

(5-iodo-2-methylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-iodo-2-Methylphenyl)Methanol

There total 5 articles about (5-iodo-2-Methylphenyl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl 5-iodo-2-methylbenzoate (612833-45-1) → (5-iodo-2-methyl-phenyl)-methanol (1260242-01-0)

Guidance literature:

ethyl 5-iodo-2-methylbenzoate; With lithium borohydride; In tetrahydrofuran; Reflux; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 0 ℃;

Reference yield:

5-iodo-2-methylbenzoic?acid (54811-38-0) → (5-iodo-2-methyl-phenyl)-methanol (1260242-01-0)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 35 - 60 ℃; for 3h;

Reference yield:

5-bromo-2-methylbenzoic acid (79669-49-1) → (5-iodo-2-methyl-phenyl)-methanol (1260242-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 15 h / 0 - 100 °C / Inert atmosphere

2.1: sodium iodide; copper(l) iodide; N,N`-dimethylethylenediamine / 15 h / 110 °C / Inert atmosphere

3.1: lithium borohydride / tetrahydrofuran / Reflux; Inert atmosphere

3.2: 0 °C

With copper(l) iodide; lithium borohydride; sodium iodide; N,N`-dimethylethylenediamine; sulfuric acid; In tetrahydrofuran;

upstream raw materials:

ethyl 5-bromo-2-methylbenzoate

ethyl 5-iodo-2-methylbenzoate

5-bromo-2-methylbenzoic acid

5-iodo-2-methylbenzoic?acid

Downstream raw materials:

2-(bromomethyl)-4-iodo-1-methylbenzene

methyl N-[(5-iodo-2-methylphenyl)methyl]carbamate

methyl N-[[5-[4-(2,4-dimethoxyphenyl)-2H-1,2,3-triazol-2-yl]-2-methylphenyl]methyl]carbamate

methyl N-[[5-(3-bromo-1H-pyrazol-1-yl)-2-methylphenyl]methyl]carbamate

Refernces

• 1、 -. "SUBSTITUTED TOLYL FUNGICIDE MIXTURES". Page/Page column 42; 43. . Retrieved 2015/11/03.
• 2、 -. "2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS". Page/Page column 60; 61. . Retrieved 2013/05/23.