TOFOGLIFLOZIN

Base Information

• Chemical Name: TOFOGLIFLOZIN
• CAS No.: 1201913-82-7
• Molecular Formula: C₂₂H₂₆O₆*2H₂O
• Molecular Weight: 422.475
• Mol file: 1201913-82-7.mol

Synonyms:(1S,3'R,4'S,5'S,6'R)-6-[(4-Ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol hydrate (1:1);Tofogliflozin hydrate (1:1);Tofogliflozin (hydrate);Tofogliflozin Monohydrate

Chemical Property of TOFOGLIFLOZIN

Chemical Property:

• PSA: 108.61000
• LogP: 0.93230

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tofogliflozinhydrate >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Tofogliflozin hydrate, which is a sodium-glucose co-transporter 2 inhibitor, was approved in Japan for the treatment of type 2 diabetes at the same time as luseogliflozin hydrate (XIX). The drug was discovered by Chugai Pharmaceutical and jointly developed with Sanofi-Aventis and Kowa. Tofogliflozin hydrate reduces glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2, and plays a key role in the reuptake of glucose in the proximal tubule of the kidneys.

Technology Process of TOFOGLIFLOZIN

There total 1 articles about TOFOGLIFLOZIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,3'R,4'S,5'S,6'R)-6-(4-ethylbenzyl)-6′-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-3',4',5'-triol (903565-83-3) → tofogliflozin dihydrate (1201913-82-7)

Guidance literature:

With water; In acetone; butan-1-ol; at 65 - 70 ℃; for 12h;

upstream raw materials:

(1R,3'R,4'S,5'S,6'R)-6-(4-ethylbenzyl)-6′-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-3',4',5'-triol

Refernces