3α,20-Dihydroxy-4,4,14-trimethyl-18-nor-5α-cholan-24-oic acid γ-lactone

Base Information

• Chemical Name: 3α,20-Dihydroxy-4,4,14-trimethyl-18-nor-5α-cholan-24-oic acid γ-lactone
• CAS No.: 35833-72-8
• Molecular Formula: C27H44O3
• Molecular Weight: 416.65
• Mol file: 35833-72-8.mol

Synonyms:3α,20-Dihydroxy-18,25,26,27-tetranor-5α-dammaran-24-oic acid 24,20-lactone;3α,20-Dihydroxy-4,4,14-trimethyl-18-nor-5α-cholan-24-oic acid γ-lactone;Cabralea hydroxylactone;Cabraleahydroxylactone;3-Epicabraleahydroxylactone

Chemical Property of 3α,20-Dihydroxy-4,4,14-trimethyl-18-nor-5α-cholan-24-oic acid γ-lactone

Chemical Property:

• Melting Point: 155-157 °C
• Boiling Point: 518.7±23.0 °C(Predicted)
• PKA: 15.18±0.70(Predicted)
• PSA: 46.53000
• Density: 1.061±0.06 g/cm3(Predicted)
• LogP: 6.12810

Purity/Quality:

98%min ^*data from raw suppliers

3-Epicabraleahydroxylactone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3α,20-Dihydroxy-4,4,14-trimethyl-18-nor-5α-cholan-24-oic acid γ-lactone

There total 1 articles about 3α,20-Dihydroxy-4,4,14-trimethyl-18-nor-5α-cholan-24-oic acid γ-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3β-Hydroxy-tris-nor-dammaran-24:20-ξ2-olid (35833-69-3,35833-72-8,107297-26-7)

Guidance literature:

Aus 3β-Hydroxy-tris-nor-dammaran-24:20ξ2-olid-acetat beim Erwaermen mit methanol. Kalilauge;

DOI:10.1139/v65-461

Reference yield:

(20S)-3β-hydroxy-25,26,27-trisnordammaran-24,20-olide (35833-72-8) → 4,4,8,14-tetramethyl-24,24-diphenyl-18-nor-5α-cholane-3β,20,24-triol

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: diethyl ether; benzene

With pyridine; diethyl ether; benzene;

DOI:10.1016/0040-4020(58)80024-1

Reference yield:

(20S)-3β-hydroxy-25,26,27-trisnordammaran-24,20-olide (35833-72-8) → 3β-acetoxy-4,4,8,14-tetramethyl-24,24-diphenyl-18-nor-5α-cholane-20,24-diol (109015-30-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: diethyl ether; benzene

3: pyridine

With pyridine; diethyl ether; benzene;

DOI:10.1016/0040-4020(58)80024-1

Downstream raw materials:

25,26,27-trinordammaran-3β-ol-20(S),24-olide hydrogen phthalate

3β-acetoxy-4,4,8,14-tetramethyl-24,24-diphenyl-18-nor-5α-cholane-20,24-diol