Methylene Blue

Base Information Edit

Chemical Name:Methylene Blue
CAS No.:97130-83-1
Deprecated CAS:105504-42-5,121067-62-7,1341-90-8,167498-52-4,6476-03-5,97130-83-1,12262-49-6,1001913-24-1,1001914-35-7,1219638-11-5,923927-02-0,1001913-24-1,1001914-35-7,1219638-11-5,12262-49-6,1341-90-8,152071-32-4,167498-52-4,6476-03-5,923927-02-0,97130-83-1
Molecular Formula:C₁₆H₁₈N₃S*Cl
Molecular Weight:319.858
Hs Code.:
European Community (EC) Number:200-515-2,686-172-3
NSC Number:759135,215213,3089,617593
UNII:8NAP7826UB
DSSTox Substance ID:DTXSID0023296
Wikipedia:Methylene_blue
Wikidata:Q422134
NCI Thesaurus Code:C175730
RXCUI:2198975
Pharos Ligand ID:RT814RHG5L5D
Metabolomics Workbench ID:152273
ChEMBL ID:CHEMBL405110
Mol file:97130-83-1.mol

Synonyms:basic blue 9;Blue 9, Basic;Blue N, Methylene;Blue, Methylene;Blue, Swiss;Blue, Urolene;Chromosmon;Methylene Blue;Methylene Blue N;Methylthionine Chloride;Methylthioninium Chloride;Swiss Blue;Urolene Blue

Suppliers and Price of Methylene Blue

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Methylene Blue Edit

Chemical Property:

PSA：47.61000
LogP:0.86660
Water Solubility.:40 g/L (20℃)
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:319.0909965
Heavy Atom Count:21
Complexity:483

Purity/Quality:: ≥99.0% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes: Xn:Harmful;
Statements: R22:; R41:;
Safety Statements: S26:; S39:;

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Dyes -> Azine Dyes
Canonical SMILES:CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]
Recent ClinicalTrials:The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer
Recent EU Clinical Trials:Photodynamic therapy of antifungal resistant dermatophytes
Recent NIPH Clinical Trials:Utility comparison test of super -magnifying endoscope for superficial duodenal epithetlial tumors (SDETs)

Technology Process of Methylene Blue

There total 32 articles about Methylene Blue which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1747-90-6
3,11-dinitro-10H-phenothiazine

: 152071-32-4,105504-42-5,121067-62-7,12262-49-6,167498-52-4,6476-03-5,97130-83-1
methylene blue

Guidance literature:: formaldehyd; 3,11-dinitro-10H-phenothiazine; With 5%-palladium/activated carbon; hydrogen; In water; N,N-dimethyl-formamide; at 20 - 90 ℃; for 18h; under 2850.29 - 45079.5 Torr;

With hydrogenchloride; iron(III) chloride hexahydrate; In water; N,N-dimethyl-formamide; at 5 ℃; for 2.5h; Time; Pressure; Concentration;

Reference yield: 52.0%

: 3763-06-2
1-[3,7-bis(dimethylamino)phenothiazin-10-yl]ethanone

: 152071-32-4,105504-42-5,121067-62-7,12262-49-6,167498-52-4,6476-03-5,97130-83-1
methylene blue

Guidance literature:: 1-[3,7-bis(dimethylamino)phenothiazin-10-yl]ethanone; With hydrogenchloride; In water; at 80 ℃; for 1h;

With iron(III) chloride; In water; at 5 - 25 ℃; for 0.166667 - 0.5h; Product distribution / selectivity;