3,6-Dichloro-4-ethylpyridazine

Base Information

• Chemical Name: 3,6-Dichloro-4-ethylpyridazine
• CAS No.: 107228-54-6
• Molecular Formula: C6H6Cl2N2
• Molecular Weight: 177.033
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80554475
• Wikidata: Q82435482
• Mol file: 107228-54-6.mol

Synonyms:3,6-dichloro-4-ethylpyridazine;107228-54-6;MFCD17014877;Pyridazine, 3,6-dichloro-4-ethyl-;3,6-Dichloro-4ethylpyridazine;SCHEMBL1188816;DTXSID80554475;YKUMFVUOUWBXTB-UHFFFAOYSA-N;AMY31143;AKOS015892481;s11033;CS-11991;SY034778;CS-0132954

Chemical Property of 3,6-Dichloro-4-ethylpyridazine

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Boiling Point: 289.813ºC at 760 mmHg
• PKA: -0.67±0.10(Predicted)
• Flash Point: 156.666ºC
• PSA: 25.78000
• Density: 1.335g/cm3
• LogP: 2.34580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 175.9908036
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

3,6-Dichloro-4-ethylpyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC(=NN=C1Cl)Cl

Technology Process of 3,6-Dichloro-4-ethylpyridazine

There total 4 articles about 3,6-Dichloro-4-ethylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

3,6-dichlorpyridazine (141-30-0) + propionic acid (802294-64-0,79-09-4) → 3,6-dichloro-4-ethylpyridazine (107228-54-6)

Guidance literature:

With ammonium peroxydisulfate; sulfuric acid; silver nitrate; In water; at 50 - 75 ℃; for 0.833333h;

Reference yield:

3,6-dichlorpyridazine (141-30-0) + propionic acid (802294-64-0,79-09-4) → 3,6-dichloro-4-ethylpyridazine (107228-54-6) + 3,6-Dichloro-4,5-diethylpyridazine (107228-53-5)

Guidance literature:

3,6-dichlorpyridazine; propionic acid; With ammonium peroxydisulfate; sulfuric acid; silver nitrate; In water; at 60 - 70 ℃; Inert atmosphere;

With ammonium hydroxide; In water; pH=7; Cooling with ice;

Reference yield:

3,6-dichlorpyridazine (141-30-0) + ammonium persulfate + ethyl acetate n-hexane → 3,6-dichloro-4-ethylpyridazine (107228-54-6)

Guidance literature:

With sulfuric acid; silver nitrate; propionic acid; In water;

upstream raw materials:

3,6-dichlorpyridazine

propionic acid

Downstream raw materials:

5-[(6-chloro-4-ethylpyridazin-3-yl)(cyano)methyl]-2-fluorobenzonitrile

5-[(6-chloro-5-ethylpyridazin-3-yl)(cyano)methyl]-2-fluorobenzonitrile

Refernces

• 1、 -. "THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS". Paragraph 0488-0489. . Retrieved 2020/05/02.
• 2、 -. "TRIAZOLIUM SALTS AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS". Page/Page column 34. . Retrieved 2011/02/26.