Chemical Property of ML234
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Chemical Property:
- Boiling Point:590.1±50.0 °C(Predicted)
- PKA:4.71±0.40(Predicted)
- PSA:65.46000
- Density:1.188±0.06 g/cm3(Predicted)
- LogP:3.67980
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble10mg/mL, clear
- Purity/Quality:
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99% *data from raw suppliers
ML324 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22
- MSDS Files:
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Useful:
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Description
ML324 (1222800-79-4) inhibits JMJD2 histone demethylases. Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 μM) and abrogates infection. ML-324 represses the reactivation of HSV from the latent state in sensory neurons.1
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Uses
ML324 is a JMJD2 demethylase inhibitor. It blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.