2-BroMo-3-(trifluoroMethyl)phenol

Base Information

• Chemical Name: 2-BroMo-3-(trifluoroMethyl)phenol
• CAS No.: 1214323-39-3
• Molecular Formula: C7H4BrF3O
• Molecular Weight: 241.007
• Hs Code.: 2908199090
• Mol file: 1214323-39-3.mol

Synonyms:2-BROMO-3-HYDROXYBENZOTRIFLUORIDE;

Chemical Property of 2-BroMo-3-(trifluoroMethyl)phenol

Chemical Property:

• Boiling Point: 205.1±35.0 °C(Predicted)
• PKA: 7.43±0.10(Predicted)
• PSA: 20.23000
• Density: 1.752±0.06 g/cm3(Predicted)
• LogP: 3.17350

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-3-(trifluoromethyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-3-(trifluoroMethyl)phenol

There total 2 articles about 2-BroMo-3-(trifluoroMethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 2-bromo-3-(trifluoromethyl)phenol (1214323-39-3)

Guidance literature:

With palladium-catalysed synthesis; In toluene; at 150 ℃; for 0.0833333h; Inert atmosphere;

Reference yield: 3.0%

3-Trifluoromethylphenol (98-17-9) → 2-bromo-3-(trifluoromethyl)phenol (1214323-39-3)

Guidance literature:

With bromine; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 78.0%

2-bromo-3-(trifluoromethyl)phenol (1214323-39-3) + 2-acetamido-2,4,6,-tri-O-acetyl-1-chloro-1,2-dideoxy-α-D-galactopyranose (41355-44-6) → (2R,3R,4R,5R,6S)-5-acetamido-2-(acetoxymethyl)-6-(2-bromo-3-(trifluoromethyl)phenoxy)tetrahydro-2H-pyran-3,4-diyl diacetate

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b01561

upstream raw materials:

3-Trifluoromethylphenol

Refernces