ethyl 4-(4-acetylphenyl)butanoate

Base Information

• Chemical Name: ethyl 4-(4-acetylphenyl)butanoate
• CAS No.: 71665-59-3
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 71665-59-3.mol

Synonyms:ethyl 4-(4-acetylphenyl)butanoate

Chemical Property of ethyl 4-(4-acetylphenyl)butanoate

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-(4-acetylphenyl)butanoate

There total 15 articles about ethyl 4-(4-acetylphenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 4-phenylbutyrate (10031-93-3) + acetyl chloride (75-36-5) → 4-(4-acetylphenyl)butyric acid ethyl ester (71665-59-3)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 1.33333h; Inert atmosphere;

DOI:10.1016/j.bmc.2018.02.008

Reference yield: 87.0%

ethyl 4-iodobutyrate (7425-53-8) + 4-Iodoacetophenone (13329-40-3) → 4-(4-acetylphenyl)butyric acid ethyl ester (71665-59-3)

Guidance literature:

ethyl 4-iodobutyrate; With indium; copper(ll) sulfate pentahydrate; In tetrahydrofuran; water; at 60 ℃; for 12h;

4-Iodoacetophenone; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In N,N-dimethyl acetamide; water; at 80 ℃; for 24h;

DOI:10.1016/j.tetlet.2019.151288

Reference yield: 84.0%

Ethyl 4-bromobutyrate (2969-81-5) + para-bromoacetophenone (99-90-1) → diethyl suberate (2050-23-9) + 4,4'-diacetylbiphenyl (787-69-9) + 4-(4-acetylphenyl)butyric acid ethyl ester (71665-59-3) + butanoic acid ethyl ester (105-54-4) + acetophenone (98-86-2)

Guidance literature:

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 1,10-Phenanthroline; NiI₂*3.5H₂O; sodium iodide; zinc; at 20 - 60 ℃; for 25h; chemoselective reaction;

DOI:10.1021/ja301769r

upstream raw materials:

ethyl 4-phenylbutyrate

acetyl chloride

4-Iodoacetophenone

Ethyl 4-bromobutyrate

Downstream raw materials:

7-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-3,4-dihydronaphthalen-1(2H)-one

2-(8-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)ethyl 4-methylbenzenesulfonate

7-acetyl-3,4-dihydro-2H-naphthalen-1-one

5,6-dihydro-7-(1H-imidazol-1-yl)-2-naphthalenecarboxylic acid

Refernces

• 1、 Su, Yong-Liang,Liu, Geng-Xin,Liu, Jun-Wen,Tram, Linh,Qiu, Huang,Doyle, Michael P.. "Radical-Mediated Strategies for the Functionalization of Alkenes with Diazo Compounds". supporting information. p. 13846 - 13855. Retrieved 2020/09/21.
• 2、 Feng, Xue-Xin,Wu, Zhen,Wang, Qing-Dong,Chen, Bing-Zhi,Rao, Weidong,Yang, Jin-Ming,Shen, Zhi-Liang. "Cesium carbonate-catalyzed indium insertion into alkyl iodides and their synthetic utilities in cross-coupling reactions". . . Retrieved 2019/07/31.