trans-Methylkhellactone

Base Information

• Chemical Name: trans-Methylkhellactone
• CAS No.: 23733-92-8
• Molecular Formula: C15H16O5
• Molecular Weight: 276.28
• Mol file: 23733-92-8.mol

Synonyms:trans-Methylkhellactone;(9R,10S)-9,10-Dihydro-9-hydroxy-10-methoxy-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one

Chemical Property of trans-Methylkhellactone

Chemical Property:

• Melting Point: 161-162℃
• PSA: 68.90000
• LogP: 2.01240

Purity/Quality:

98%Min ^*data from raw suppliers

trans-Methylkhellactone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-Methylkhellactone

There total 8 articles about trans-Methylkhellactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) → trans-4'-O-methylkhellactone (23733-92-8)

Guidance literature:

With hydrogenchloride;

Reference yield:

methanol (67-56-1) + (9R,10R)-9-acetoxy-8,8-dimethyl-9,10-dihydro-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one-10-yl ester → (-)-trans-khellactone 4'-methyl ether (20107-13-5) + trans-4'-O-methylkhellactone (23733-92-8)

Guidance literature:

With hydrogenchloride; for 22h; Heating;

DOI:10.1021/np010448t

Reference yield:

(+)-samidin (477-33-8) → trans-4'-O-methylkhellactone (23733-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane; aqueous KOH-solution

2: hydrogen chloride

With 1,4-dioxane; hydrogenchloride; potassium hydroxide;

upstream raw materials:

methanol

(+)-cis-khellactone

trans-kellactone

(+)-samidin

Refernces

• 1、 Widelski, Jarek,Melliou, Eleni,Fokialakis, Nikolas,Magiatis, Prokopios,Glowniak, Kazimierz,Chinou, Ioanna. "Coumarins from the fruits of Seseli devenyense". . p. 1637 - 1641. Retrieved 2008/09/17.