Sargramostim

Base Information

• Chemical Name: Sargramostim
• CAS No.: 123774-72-1
• Molecular Weight: 0
• Hs Code.: 3504009000
• Mol file: 123774-72-1.mol

Synonyms:B 161.012;BI 61.012; Leucogen; Leukine; Mielogen; Mielogen (hormone); Prokine;Sargramostim; rhuGM-CSF

Chemical Property of Sargramostim

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

rHuGM-CSF ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Sargramostim, a recombinant DNA product, is a granulocyte macrophage colony stimulating factor (GM-CSF) indicated for the treatment of cancer patients after autologous bone marrow transplants. It stimulates immature cells to develop into granulocytes and macrophages and can also switch on mature granulocytes and macrophages.Other indications include improved bone m m w recovery in non-Hodgkins lymphoma and acute lymphoblastic leukemia.
• Uses: Antineutropenic; hematopoietic stimulant.
• Indications: Sargramostim (GM-CSF, Leukine, Prokine) is a human recombinant granulocyte and macrophage colony– stimulating factor that stimulates the production and potentiates the function of both granulocytes and macrophages from hematopoietic progenitor cells. It is used to accelerate bone marrow repopulation after high-dose chemotherapy, radiation therapy, and bone marrow transplantation. Adverse effects associated with sargramostim use include bone pain (similar to that of filgrastim), fatigue, fevers, skin rash, malaise, and fluid retention.
• Clinical Use: Sargramostim binds to specific receptors on target cellsand induces proliferation, activation, and maturation.Administration to patients causes a dose-related increase inthe peripheral white blood cell count. Unlike G-CSF, GMCSFis a multilineage hematopoietic growth factor that inducespartially committed progenitor cells to proliferate anddifferentiate along the granulocyte and the macrophage pathways.It also enhances the function of mature granulocytesand macrophages/monocytes. GM-CSF increases the chemotactic,antifungal, and antiparasitic activities of granulocytesand monocytes. It also increases the cytotoxicity of monocytestoward neoplastic cell lines and activates polymorphonuclearleukocytes to inhibit the growth of tumor cells.Sargramostim is used to reconstitute the myeloid tissueafter autologous bone marrow transplant and followingchemotherapy in acute myelogenous leukemia. The preparationdecreases the incidence of infection, decreases the numberof days that antibiotics are required, and decreases theduration of hospital stays.