(R)-N-Acetyl-5-Fluoro-Trp-OMe

Base Information

• Chemical Name: (R)-N-Acetyl-5-Fluoro-Trp-OMe
• CAS No.: 114872-80-9
• Molecular Formula: C14H15FN2O3
• Molecular Weight: 278.28
• Mol file: 114872-80-9.mol

Synonyms:(R)-N-Acetyl-5-Fluoro-Trp-OMe;N-Acetyl-5-fluoro-D-tryptophan methyl ester

Chemical Property of (R)-N-Acetyl-5-Fluoro-Trp-OMe

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 514.69°C at 760 mmHg
• Flash Point: 265.075°C
• PSA: 71.19000
• Density: 1.296g/cm³
• LogP: 1.91810
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-N-Acetyl-5-fluoro-trp-OMe ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-Acetyl-5-Fluoro-Trp-OMe

There total 2 articles about (R)-N-Acetyl-5-Fluoro-Trp-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-fluoro-1H-indole (399-52-0) + Methyl 2-acetamidoacrylate (35356-70-8) → 5-fluoro-Nα-acetyltryptophan methyl ester (114872-70-7,114872-80-9)

Guidance literature:

With ethylaluminum dichloride; In hexane; dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jo800881u

Reference yield:

methanol (67-56-1) + Nα-acetyl-5-fluoro-L-tryptophan (114872-75-2) → Nα-acetyl-5-fluoro-L-tryptophan methyl ester (1029430-18-9,114872-80-9)

Guidance literature:

With sulfuric acid; for 2h; Heating;

DOI:10.1016/j.tetlet.2008.02.120

upstream raw materials:

methanol

N^α-acetyl-5-fluoro-L-tryptophan

5-fluoro-1H-indole

Methyl 2-acetamidoacrylate

Refernces

• 1、 Angelini, Elena,Balsamini, Cesarino,Bartoccini, Francesca,Lucarini, Simone,Piersanti, Giovanni. "Switchable reactivity of acylated α,β-dehydroamino ester in the Friedel-Crafts alkylation of indoles by changing the lewis acid". . p. 5654 - 5657. Retrieved 2008/12/21.