N-(4-Mesitylthiazol-2-yl)benzaMide

Base Information

• Chemical Name: N-(4-Mesitylthiazol-2-yl)benzaMide
• CAS No.: 1001753-24-7
• Molecular Formula: C19H18N2OS
• Molecular Weight: 322.431
• Mol file: 1001753-24-7.mol

Synonyms:N-(4-Mesitylthiazol-2-yl)benzaMide;INH6;N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide

Chemical Property of N-(4-Mesitylthiazol-2-yl)benzaMide

Chemical Property:

• PSA: 70.23000
• LogP: 5.06060
• Solubility.: ≥32.2 mg/mL in DMSO; insoluble in H2O; ≥3.55 mg/mL in EtOH with gentle warming and ultrasonic

Purity/Quality:

98%min ^*data from raw suppliers

INH6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: INH6 is a Hec1 inhibitor that targets the Hec1/Nek2 pathway and causes chromosome mis-alignment as well as cell death.

Technology Process of N-(4-Mesitylthiazol-2-yl)benzaMide

There total 1 articles about N-(4-Mesitylthiazol-2-yl)benzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

4-(2,4,6-trimethylphenyl)thiazol-2-ylamine (81529-60-4) + benzoyl chloride (98-88-4) → N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide (1001753-24-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 2.5h; Reflux;

DOI:10.1021/jm8015969

Reference yield: 89.0%

N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide (1001753-24-7) + methyl iodide (74-88-4) → N-methyl-N-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]benzamide (1134986-31-4)

Guidance literature:

N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

DOI:10.1021/jm8015969

Reference yield: 72.0%

N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide (1001753-24-7) + ethyl bromoacetate (105-36-2) → {benzoyl-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]-amino}acetic acid ethyl ester (1134986-42-7)

Guidance literature:

N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 90 ℃;

ethyl bromoacetate; In N,N-dimethyl-formamide; mineral oil; at 0 - 90 ℃;

DOI:10.1021/jm8015969

upstream raw materials:

4-(2,4,6-trimethylphenyl)thiazol-2-ylamine

benzoyl chloride

Downstream raw materials:

N-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethyl)-N-[4-(2,4,6-trimethyl-phenyl)-thiazol-2-yl]benzamide

{benzoyl-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]-amino}acetic acid ethyl ester

N-methyl-N-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]benzamide

Refernces