rac 4-Desmethoxy-4-nitro Omeprazole

Base Information

• Chemical Name: rac 4-Desmethoxy-4-nitro Omeprazole
• CAS No.: 317807-10-6
• Molecular Formula: C₁₆H₁₆N₄O₄S
• Molecular Weight: 360.393
• Mol file: 317807-10-6.mol

Synonyms:5-Methoxy-2-{(S)-[(4-nitro-3,5-dimethyl-pyridine-2-yl)methyl]sulfinyl}-1H-benzimidazol;2-[[(3,5-Dimethyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-5-methoxy-1H-benzimidazole;rac 4-Desmethoxy-4-nitro Omeprazole;5-Methoxy-2-[(S)-[(4-nitro-3,5-dimethyl-pyridine-2-yl)methyl]sulfinyl]-1H-benzimidazole;4-DesMethoxy-4-nitro OMeprazole

Chemical Property of rac 4-Desmethoxy-4-nitro Omeprazole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 652.094°C at 760 mmHg
• PKA: 8.74±0.10(Predicted)
• Flash Point: 348.174°C
• PSA: 132.90000
• Density: 1.494g/cm³
• LogP: 4.18820
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-Desmethoxy-4-nitro Omeprazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Impurity C from the synthesis of Omeprazole.

Technology Process of rac 4-Desmethoxy-4-nitro Omeprazole

There total 1 articles about rac 4-Desmethoxy-4-nitro Omeprazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxy-2-(((3,5-dimethyl-4-nitro-2-pyridinyl)methyl)thio)-1H-benzimidazole (142885-91-4) → (S)-5-methoxy-2-[[(3,5-dimethyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole (317807-10-6)

Guidance literature:

5-methoxy-2-(((3,5-dimethyl-4-nitro-2-pyridinyl)methyl)thio)-1H-benzimidazole; With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; In water; ethyl acetate; at 35 ℃; for 1h;

With Cumene hydroperoxide; N-ethyl-N,N-diisopropylamine; In water; ethyl acetate; at 25 - 35 ℃; for 12.25h;

upstream raw materials:

5-methoxy-2-(((3,5-dimethyl-4-nitro-2-pyridinyl)methyl)thio)-1H-benzimidazole

Refernces

• 1、 -. "A PROCESS FOR THE PREPARATION OF SUBSTITITED PYRIDINYLMETHYLSULFINYL- BENZIMIDAZOLE ENANTIOMERS". Page/Page column 8. . Retrieved 2008/06/13.