FlubroMazolaM

Base Information

• Chemical Name: FlubroMazolaM
• CAS No.: 612526-40-6
• Molecular Formula: C17H12BrFN4
• Molecular Weight: 371.211
• Mol file: 612526-40-6.mol

Synonyms:FlubroMazolaM

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Chemical Property of FlubroMazolaM

Chemical Property:

• Boiling Point: 520.6±60.0 °C(Predicted)
• PKA: 2.27±0.40(Predicted)
• PSA: 43.07000
• Density: 1.60±0.1 g/cm3(Predicted)
• LogP: 3.26390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FlubroMazolaM

There total 3 articles about FlubroMazolaM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

acetic acid hydrazide (1068-57-1) → flubromazolam (612526-40-6)

Guidance literature:

7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

With di-morpholin-4-yl-phosphinic acid chloride; In tetrahydrofuran; at 20 ℃; for 2h;

acetic acid hydrazide; In tetrahydrofuran; butan-1-ol; at 20 ℃; for 0.166667h;

Reference yield: 40.0%

acetic acid hydrazide (1068-57-1) + 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one (2647-50-9) → flubromazolam (612526-40-6)

Guidance literature:

7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

With di-morpholin-4-yl-phosphinic acid chloride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

acetic acid hydrazide; In tetrahydrofuran; butan-1-ol; at 20 ℃; for 2.25h; Heating / reflux;

Reference yield:

→ flubromazolam (612526-40-6)

Guidance literature:

upstream raw materials:

acetic acid hydrazide

7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

Downstream raw materials:

6-(2-fluorophenyl)-1-methyl-8-[(trimethylsilyl) ethynyl]-4H-[1,2,4]triazolo [4,3-a][1,4]benzodiazepine

Refernces

• 1、 -. "Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects". Page/Page column 32. . Retrieved 2008/06/13.