(R)-b-AMino-3-broMo-benzeneethanol

Base Information

• Chemical Name: (R)-b-AMino-3-broMo-benzeneethanol
• CAS No.: 209963-04-2
• Molecular Formula: C8H10BrNO
• Molecular Weight: 216.0751
• Hs Code.: 2922190090
• Mol file: 209963-04-2.mol

Synonyms:(R)-b-AMino-3-broMo-benzeneethanol;(2R)-2-AMINO-2-(3-BROMOPHENYL)ETHAN-1-OL;(2R)-2-AMINO-2-(3-BROMOPHENYL)ETHAN-1-OL HCl;(R)-2-amino-2-(3-bromophenyl)ethan-1-ol;(R)-2-Amino-2-(3-bromophenyl)ethanol;Benzeneethanol, β-amino-3-bromo-, (βR)-

Chemical Property of (R)-b-AMino-3-broMo-benzeneethanol

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

95% ^*data from raw suppliers

(R)-2-Amino-2-(3-bromophenyl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-b-AMino-3-broMo-benzeneethanol

There total 7 articles about (R)-b-AMino-3-broMo-benzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-2-azido-2-(3-bromophenyl)ethan-1-ol → (R)-2-amino-2-(3-bromophenyl)ethanol (209963-04-2,209963-05-3)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 70 ℃;

DOI:10.1016/j.tetasy.2015.12.002

Reference yield:

α-amino-3-bromophenylacetic acid (79422-73-4,150174-93-9) → (±)-2-amino-2-(3-bromophenyl)ethanol (209963-04-2,209963-05-3)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0 ℃; for 20h; Reflux;

Reference yield:

ethyl N-(3-bromophenyl)glycinate (2521-91-7) → (±)-2-amino-2-(3-bromophenyl)ethanol (209963-04-2,209963-05-3)

Guidance literature:

In sodium borohydrid; ethanol; water;

upstream raw materials:

ethyl N-(3-bromophenyl)glycinate

α-amino-3-bromophenylacetic acid

3-bromostyrene

(S)-(+)-2-(3-bromophenyl)oxirane

Downstream raw materials:

2-[6-(3-chloro-phenyl)-pyrazin-2-ylamino]-2-(3-bromo-phenyl)-ethanol

(S)-tert-butyl (1-(3-bromophenyl)-2-hydroxyethyl)carbamate

Refernces

• 1、 Wang, Hai-Yang,Huang, Kun,De Jesús, Melvin,Espinosa, Sandraliz,Pi?ero-Santiago, Luis E.,Barnes, Charles L.,Ortiz-Marciales, Margarita. "Synthesis of enantiopure 1,2-azido and 1,2-amino alcohols via regio- and stereoselective ring-opening of enantiopure epoxides by sodium azide in hot water". . p. 91 - 100. Retrieved 2016/02/09.
• 2、 -. "Pharmaceutical compositions containing a 4, 5-dihydro-1, 3-thiazol-2-ylamine derivative, novel derivatives and preparation thereof". . . Retrieved 2011/05/18.