(±)-α,α,4-trimethylcyclohex-3-ene-1-methanol

Base Information

• Chemical Name: (±)-α,α,4-trimethylcyclohex-3-ene-1-methanol
• CAS No.: 2438-12-2
• Molecular Formula: C10H18O
• Molecular Weight: 154.24932
• Mol file: 2438-12-2.mol

Synonyms:(±)-alpha,alpha,4-trimethylcyclohex-3-ene-1-methanol

Chemical Property of (±)-α,α,4-trimethylcyclohex-3-ene-1-methanol

Chemical Property:

• Melting Point: 31-34℃
• Refractive Index: 1.4723 (estimate)
• Boiling Point: 220°C (estimate)
• Flash Point: 90℃
• PSA: 20.23000
• Density: 0.936
• LogP: 2.50370
• Water Solubility.: negligible

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi:Irritant
• Statements: R38:Irritating to skin.
• Safety Statements: S37:Wear suitable gloves.

MSDS Files:

Useful:

Technology Process of (±)-α,α,4-trimethylcyclohex-3-ene-1-methanol

There total 229 articles about (±)-α,α,4-trimethylcyclohex-3-ene-1-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methylmagnesium bromide (75-16-1) + phenylmethyl-(4R)-1-methylcyclohexene-4-carboxylate (90719-47-4) → 4R-α-terpineol (7785-53-7,2438-12-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 13h;

DOI:10.1039/b605346g

Reference yield: 53.0%

(4R)-(+)-α-terpinyl acetate (7785-54-8) → 4R-α-terpineol (7785-53-7,2438-12-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; at 65 ℃; for 48h;

Reference yield: 52.0%

trans-sobrerol (38235-58-4) → 4R-α-terpineol (7785-53-7,2438-12-2)

Guidance literature:

With triethylsilane; lithium perchlorate; In diethyl ether; for 16h; Ambient temperature;

DOI:10.1016/0040-4039(94)88162-6

upstream raw materials:

1,4-dioxane

rac-α-pinene

benzenesulfonic acid

methyl magnesium iodide

Downstream raw materials:

(+)-O-(3.5-dinitro-benzoyl)-α-terpineol

2,2,6-trimethyl-4-phenyl-3-oxabicyclo<3.3.1>non-6-ene

(+)-O-(4-Nitro-benzoyl)-α-terpineol

α-Terpineol-2,4-dinitrophenyl-ether

Refernces

• 1、 ?erveny, Libor,Vysko?ilová, Eli?ka,Zítová, Kate?ina. "Preparation of α-terpineol and perillyl alcohol using zeolites beta". . p. 4297 - 4310. Retrieved 2021.
• 2、 ávila, Maria C.,Comelli, Nora A.,Rodríguez-Castellón,Jiménez-López,Carrizo Flores,Ponzi,Ponzi. "Study of solid acid catalysis for the hydration of α-pinene". . p. 106 - 112. Retrieved 2010.
• 3、 Zhang, Q.,Tiefenbacher, K.. "Terpene cyclization catalysed inside a self-assembled cavity". . p. 197 - 202. Retrieved 2015.
• 4、 Sekerová, Lada,?erná, Hana,Vysko?ilová, Eli?ka,Vrbková, Eva,?erveny, Libor. "Preparation of α-Terpineol from Biomass Resource Catalysed by Acid Treated Montmorillonite K10". . p. 2673 - 2683. Retrieved 2021.
• 5、 Wustrow, David J.,Smith, William J.,Wise, Lawrence D.. "Selective Deoxygenation of Allylic Alcohols and Acetates by Lithium Perchlorate Promoted Triethylsilane Reduction". . p. 61 - 64. Retrieved 1994.
• 6、 Einhorn, J.,Einhorn, C.,Luche, J. L.. "Ultrasound in Organic Synthesis. 18. Selective Oxymercuration via Sonochemically in Situ Generated Mercury Salts". . p. 4479 - 4481. Retrieved 1989.
• 7、 Argade, Malaika D.,Straub, Carolyn J.,Rusali, Lisa E.,Santarsiero, Bernard D.,Riley, Andrew P.. "Synthesis of Aristoquinoline Enantiomers and Their Evaluation at the α3β4 Nicotinic Acetylcholine Receptor". . p. 7693 - 7697. Retrieved 2021/08/16.